All Phenotypes Grm6<nob4> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Grm6^nob4
no b wave 4
MGI:3580353

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grm6^nob4/Grm6^nob4	C57BL/6J-Grm6^nob4	MGI:3580354
hm2	Grm6^nob4/Grm6^nob4	involves: C57BL/6J	MGI:4880736
ht3	Grm6^nob3/Grm6^nob4	involves: C57BL/6J * C57BL/10 * DBA/2	MGI:4880735

Allelic Composition	Grm6^nob4/Grm6^nob4
Genetic Background	C57BL/6J-Grm6^nob4

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grm6^nob4 mutation (0 available); any Grm6 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eye electrophysiology ( J:98867 )

• electroretinograms (ERGs) of dark-adapted 12 week old mutant mice lack the rod b-wave and scotopic threshold response (STR), although the cone electroretinograms are of high amplitude

Allelic Composition	Grm6^nob4/Grm6^nob4
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grm6^nob4 mutation (0 available); any Grm6 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eye physiology ( J:152828 )

• ON retinal ganglion cell responses are delayed compared to in wild-type mice

• the spatial frequency cutoffs are lower than in wild-type mice

• however, peak contrast sensitivity is normal

abnormal cone electrophysiology ( J:152828 )

• photopic b-waves are absent

• however, a-waves are normal

abnormal rod electrophysiology ( J:152828 )

• scotopic b-waves are absent

• mice lack a scotopic threshold response unlike wild-type mice

• however, a-waves are normal

Allelic Composition	Grm6^nob3/Grm6^nob4
Genetic Background	involves: C57BL/6J * C57BL/10 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grm6^nob3 mutation (1 available); any Grm6 mutation (53 available)
Grm6^nob4 mutation (0 available); any Grm6 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eye physiology ( J:152828 )

• spatial frequency threshold is lower than in wild-type mice

• the spatial frequency cutoffs are lower than in wild-type mice

• however, peak contrast sensitivity is normal

abnormal cone electrophysiology ( J:152828 )

• photopic b-waves are absent

• however, a-waves are normal

abnormal rod electrophysiology ( J:152828 )

• scotopic b-waves are absent

• mice lack a scotopic threshold response unlike wild-type mice

• however, a-waves are normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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