About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Frs2tm3Scl
targeted mutation 3, J Schlessinger
MGI:3580390
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Frs2tm3Scl/Frs2tm3Scl either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Swiss Webster) MGI:3581136


Genotype
MGI:3581136
hm1
Allelic
Composition
Frs2tm3Scl/Frs2tm3Scl
Genetic
Background
either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Swiss Webster)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Frs2tm3Scl mutation (0 available); any Frs2 mutation (63 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• died over a range of stages (between E5.75 and E8), with approximately half dying shortly after implantation, and the remaining half surviving through E7.5 with growth and primitive streak defects (J:98883)
• die between E7 and E7.5 as a result of severe impairment in embryonic development (J:98901)

embryo
• impaired anterior-posterior axis formation
• severely growth retarded at E7.5-E8
• 30% smaller than wild-type at E7
• trophoblast stem cells failed to develop and proliferate in response to FGF4 when grown in culture
• fail to assemble a properly elongating primitive streak in the posterior region
• thickened visceral endoderm at the distal region of the egg cylinder at E7

growth/size/body
• severely growth retarded at E7.5-E8
• 30% smaller than wild-type at E7





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/22/2024
MGI 6.24
The Jackson Laboratory