mortality/aging
embryonic lethality between implantation and somite formation, complete penetrance
(
J:98883
, J:98901
)
• died over a range of stages (between E5.75 and E8), with approximately half dying shortly after implantation, and the remaining half surviving through E7.5 with growth and primitive streak defects
(J:98883)
• die between E7 and E7.5 as a result of severe impairment in embryonic development
(J:98901)
|
embryo
• impaired anterior-posterior axis formation
|
• severely growth retarded at E7.5-E8
|
• 30% smaller than wild-type at E7
|
• trophoblast stem cells failed to develop and proliferate in response to FGF4 when grown in culture
|
• fail to assemble a properly elongating primitive streak in the posterior region
|
• thickened visceral endoderm at the distal region of the egg cylinder at E7
|
growth/size/body
• severely growth retarded at E7.5-E8
|
• 30% smaller than wild-type at E7
|