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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Frs2tm3Scl
targeted mutation 3, J Schlessinger
MGI:3580390
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Frs2tm3Scl/Frs2tm3Scl either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Swiss Webster) MGI:3581136


Genotype
MGI:3581136
hm1
Allelic
Composition
Frs2tm3Scl/Frs2tm3Scl
Genetic
Background
either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Swiss Webster)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Frs2tm3Scl mutation (0 available); any Frs2 mutation (63 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• died over a range of stages (between E5.75 and E8), with approximately half dying shortly after implantation, and the remaining half surviving through E7.5 with growth and primitive streak defects (J:98883)
• die between E7 and E7.5 as a result of severe impairment in embryonic development (J:98901)

embryo
• impaired anterior-posterior axis formation
• severely growth retarded at E7.5-E8
• 30% smaller than wild-type at E7
• trophoblast stem cells failed to develop and proliferate in response to FGF4 when grown in culture
• fail to assemble a properly elongating primitive streak in the posterior region
• thickened visceral endoderm at the distal region of the egg cylinder at E7

growth/size/body
• severely growth retarded at E7.5-E8
• 30% smaller than wild-type at E7





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory