Phenotypes associated with this allele

• Allele Symbol: Plag1^tm1Wjmv
• Allele Name: targeted mutation 1, Wim J M Van de Ven
• Allele ID: MGI:3580633
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plag1^tm1Wjmv/Plag1^tm1Wjmv	involves: 129S1/Sv * 129X1/SvJ * Swiss Webster	MGI:3581152

Genotype
MGI:3581152

hm1

• Allelic Composition: Plag1^tm1Wjmv/Plag1^tm1Wjmv
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

decreased prostate gland ventral lobe weight ( J:96846 )

♂ • the ventral prostate is disproportionately reduced in weight

abnormal seminal vesicle morphology ( J:96846 )

♂ • atrophic seminal vesicles and mucosa containing hyperplastic epithelium rich in secretory granules are seen

decreased seminal vesicle weight ( J:96846 )

♂ • the seminal vesicles are disproportionately reduced in weight

seminal vesicle atrophy ( J:96846 )

♂

decreased litter size ( J:96846 )

• litter size is slightly reduced for homozygous females mated with wild-type males; however, the rate of pregnancy is normal

reduced male fertility ( J:96846 )

♂ • only 7% of wild-type females housed with homozygous males became pregnant compared to 20% housed with wild-type males; however litter size was normal

growth/size/body

decreased embryo weight ( J:96846 )

• from E11.5 onwards homozygotes are smaller than wild-type littermates reaching only 70% of the weight of wild-type at birth; however, placental weight is similar to wild-type

postnatal growth retardation ( J:96846 )

• the rate of weight gain is lower in mutants such that by 21 days of age homozygotes weigh 50% that of wild-type; however, by 60 days of age mutants have caught up slightly reaching about 65% of wild-type weight

vision/eye

delayed eyelid opening ( J:96846 )

• eyes open several days later, some after weaning

endocrine/exocrine glands

decreased prostate gland ventral lobe weight ( J:96846 )

♂ • the ventral prostate is disproportionately reduced in weight

abnormal seminal vesicle morphology ( J:96846 )

♂ • atrophic seminal vesicles and mucosa containing hyperplastic epithelium rich in secretory granules are seen

decreased seminal vesicle weight ( J:96846 )

♂ • the seminal vesicles are disproportionately reduced in weight

seminal vesicle atrophy ( J:96846 )

♂

embryo

decreased embryo weight ( J:96846 )

• from E11.5 onwards homozygotes are smaller than wild-type littermates reaching only 70% of the weight of wild-type at birth; however, placental weight is similar to wild-type