About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tssk6tm1Grj
targeted mutation 1, Gibbes R Johnson
MGI:3580646
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tssk6tm1Grj/Tssk6tm1Grj involves: 129 * C57BL/6 MGI:3581024
ht2
 		Tssk6tm1Grj/Tssk6+ involves: 129 * C57BL/6 MGI:3581025


Genotype
MGI:3581024
hm1
Allelic
Composition		 Tssk6tm1Grj/Tssk6tm1Grj
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tssk6tm1Grj mutation (0 available); any Tssk6 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
asthenozoospermia ( J:98891 )
• decrease in sperm motility rates
abnormal spermatogenesis ( J:98891 )
• reduced DNA compaction in the heads of spermatozoa
oligozoospermia ( J:98891 )
• more than 50% reduction in sperm numbers and decreased percentage of motile sperm
abnormal sperm head morphology ( J:98891 )
• exhibited abnormal head morphology such as failure to develop hook-shaped heads, irregular-shaped and degenerate heads, and improper attachment of the midpiece
• expanded perinuclear and subacrosomal space and accumulation of electron-dense matter between the membranes of the head and nucleus in elongating spermatids and maturing sperm
male infertility ( J:98891 )
• males were sterile although they were sexually active and produced vaginal plugs

cellular
oligozoospermia ( J:98891 )
• more than 50% reduction in sperm numbers and decreased percentage of motile sperm
abnormal sperm head morphology ( J:98891 )
• exhibited abnormal head morphology such as failure to develop hook-shaped heads, irregular-shaped and degenerate heads, and improper attachment of the midpiece
• expanded perinuclear and subacrosomal space and accumulation of electron-dense matter between the membranes of the head and nucleus in elongating spermatids and maturing sperm
asthenozoospermia ( J:98891 )
• decrease in sperm motility rates




Genotype
MGI:3581025
ht2
Allelic
Composition		 Tssk6tm1Grj/Tssk6+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tssk6tm1Grj mutation (0 available); any Tssk6 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
oligozoospermia ( J:98891 )
• about 50% reduction in sperm count

cellular
oligozoospermia ( J:98891 )
• about 50% reduction in sperm count




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory