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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tssk6tm1Grj
targeted mutation 1, Gibbes R Johnson
MGI:3580646
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tssk6tm1Grj/Tssk6tm1Grj involves: 129 * C57BL/6 MGI:3581024
ht2
 		Tssk6tm1Grj/Tssk6+ involves: 129 * C57BL/6 MGI:3581025


Genotype
MGI:3581024
hm1
Allelic
Composition		 Tssk6tm1Grj/Tssk6tm1Grj
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tssk6tm1Grj mutation (0 available); any Tssk6 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
asthenozoospermia ( J:98891 )
• decrease in sperm motility rates
abnormal spermatogenesis ( J:98891 )
• reduced DNA compaction in the heads of spermatozoa
oligozoospermia ( J:98891 )
• more than 50% reduction in sperm numbers and decreased percentage of motile sperm
abnormal sperm head morphology ( J:98891 )
• exhibited abnormal head morphology such as failure to develop hook-shaped heads, irregular-shaped and degenerate heads, and improper attachment of the midpiece
• expanded perinuclear and subacrosomal space and accumulation of electron-dense matter between the membranes of the head and nucleus in elongating spermatids and maturing sperm
male infertility ( J:98891 )
• males were sterile although they were sexually active and produced vaginal plugs

cellular
oligozoospermia ( J:98891 )
• more than 50% reduction in sperm numbers and decreased percentage of motile sperm
abnormal sperm head morphology ( J:98891 )
• exhibited abnormal head morphology such as failure to develop hook-shaped heads, irregular-shaped and degenerate heads, and improper attachment of the midpiece
• expanded perinuclear and subacrosomal space and accumulation of electron-dense matter between the membranes of the head and nucleus in elongating spermatids and maturing sperm
asthenozoospermia ( J:98891 )
• decrease in sperm motility rates




Genotype
MGI:3581025
ht2
Allelic
Composition		 Tssk6tm1Grj/Tssk6+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tssk6tm1Grj mutation (0 available); any Tssk6 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
oligozoospermia ( J:98891 )
• about 50% reduction in sperm count

cellular
oligozoospermia ( J:98891 )
• about 50% reduction in sperm count




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory