Phenotypes associated with this allele

• Allele Symbol: Sphk2^{Gt(NPX039)Byg}
• Allele Name: gene trap NPX039, BayGenomics
• Allele ID: MGI:3580701
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sphk2^Gt(NPX039)Byg/Sphk2^Gt(NPX039)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:3618239

Genotype
MGI:3618239

hm1

• Allelic Composition: Sphk2^{Gt(NPX039)Byg}/Sphk2^{Gt(NPX039)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:102911 )

• when treated with 0.3 mg/kg of FTY720 (a sphingosine 1-phosphate receptor agonist) no reduction in total blood lymphocyte numbers is seen unlike in controls where lymphocyte numbers are reduced by 80%

• FTY720 also fails to ablate B cells in the marginal zone of the spleen or deplete lymphocytes from the efferent sinuses of the lymph nodes unlike in controls

immune system

immune system phenotype ( J:102911 )

N • in the absence of treatment total lymphocyte cellularity and fractional distribution is not different from wild-type