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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trbv15tm1Krg
targeted mutation 1, Michael S Krangel
MGI:3581023
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trbv15tm1Krg/Trbv15tm1Krg involves: 129S/SvEv * C57BL/6 MGI:3584006


Genotype
MGI:3584006
hm1
Allelic
Composition		 Trbv15tm1Krg/Trbv15tm1Krg
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trbv15tm1Krg mutation (0 available); any Trbv15 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:95669 )
N
• thymocyte development appears normal with respect to cell number and CD4 and CD8 expression; however in double negative thymocytes V12 rearrangement is increased and in double positive thymocytes V12 transcription and accessibility are increased




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory