normal phenotype
• transgenic mice with no cre expression developed normally with no significant cardiac phenotype
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Allele Symbol Allele Name Allele ID |
Tg(Myh6-GFP,MAP2K3)58Ywa transgene insertion 58, Yibin Wang MGI:3581033 |
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Summary |
2 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• transgenic mice with no cre expression developed normally with no significant cardiac phenotype
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• hemizygous or homozygous mice for Tg(Myh6-GFP,MAP2K3)58Ywa that are also heterozygous for Myl2tm1(cre)Krc, in which cre mediated recombination is induced in cardiac muscle, display premature death between 5 and 7 weeks of age
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• pulmonary edema
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• sign of dyspnea around time of death
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• pulmonary edema
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• heterogeneous myocyte atrophy
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• profoundly enlarged atria
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• increased atrial mass often filled with thrombosis
• external dimensions, and mass of ventricles are normal
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• trichrome staining shows substantial interstitial fibrotic tissues
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• systolic contractile depression and restrictive diastolic abnormalities
• increased end-systolic chamber volumes
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• heterogeneous myocyte atrophy
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• increased atrial mass often filled with thrombosis
• external dimensions, and mass of ventricles are normal
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• trichrome staining shows substantial interstitial fibrotic tissues
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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