Analysis Tools
mortality/aging
|
• remaining mice die by 3-4 weeks of age
|
|
• death on or before P1 exhibited in some mice
|
|
• CNS defects cause embryonic lethality in some mice
|
craniofacial
cranioschisis
(
J:98949
)
|
• some E14.5 embryos exhibited the abnormal brain morphology of ectopic masses with exencephalic defects
|
|
• some mice exhibited forehead protusions
|
skeleton
cranioschisis
(
J:98949
)
|
• some E14.5 embryos exhibited the abnormal brain morphology of ectopic masses with exencephalic defects
|
nervous system
|
• observed at P1
|
|
• thinner and longer pituitary gland in neonates
|
hydrocephaly
(
J:98949
)
|
• prominent in 3-4 week old moribund mice
|
|
• rostral expansion of the forebrain
|
|
• expansion of the midbrain caused cranial enlargement observed at P1
|
|
• the hypothalamus was reduced in size
|
|
• the thalamus was reduced in size
|
|
• overgrowth of cortical neural tissue is evident in histological brain sections
• brain dissection revealed severe damage to the neocortex with most of the cellular contents replaced by cerebrospinal fluid
|
exencephaly
(
J:98949
)
|
• some E14.5 embryos exhibited the abnormal brain morphology of ectopic masses with exencephalic defects
• also detected at P1
|
cardiovascular system
|
• observed at P1
|
endocrine/exocrine glands
|
• thinner and longer pituitary gland in neonates
|
|
• total thymic cellularity was reduced 100-fold
|
immune system
|
• total thymic cellularity was reduced 100-fold
|
|
• spleen weight was increased 15-fold
|
|
• splenic cellularity was increased 4-fold
|
|
• lymphopenia
• impaired lymphocyte homeostatsis
|
|
• splenic B cell numbers were decreased 50-fold
|
|
• pre-B cells were not detected in the BM
|
|
• splenic T cell numbers were decreased 50-fold
|
hematopoietic system
|
• total thymic cellularity was reduced 100-fold
|
|
• spleen weight was increased 15-fold
|
|
• splenic cellularity was increased 4-fold
|
|
• lymphopenia
• impaired lymphocyte homeostatsis
|
|
• splenic B cell numbers were decreased 50-fold
|
|
• pre-B cells were not detected in the BM
|
|
• splenic T cell numbers were decreased 50-fold
|
cellular
|
• T cells were slightly resistant to in vitro activation-induced cell death induced by gamma irradiation
|
growth/size/body
|
• some mice exhibited forehead protusions
|
|
• more than half of the mice that survived until wean age exhibited severe wasting and achieved only about 50% of normal body weight by age 3-4 weeks
• some mice became moribund at the age of 3-4 weeks, loosing about 15-20% of their body weight within 2-3 days
|
|
• spleen weight was increased 15-fold
|
|
• splenic cellularity was increased 4-fold
|
behavior/neurological
|
• uncoordinated walk
|
|
• occasional
|
|
• a bias toward one direction or the other
|
