Phenotypes associated with this allele

• Allele Symbol: Kras^tm1(Hras)Rdl
• Allele Name: targeted mutation 1, Roberto Di Lauro
• Allele ID: MGI:3581451
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kras^tm1(Hras)Rdl/Kras^tm1(Hras)Rdl	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)	MGI:3582945

Genotype
MGI:3582945

hm1

• Allelic Composition: Kras^tm1(Hras)Rdl/Kras^tm1(Hras)Rdl
• Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased myocardial fiber size ( J:98940 )

• increased cardiomyocyte area

cardiac fibrosis ( J:98940 )

• increased fibrosis in the left ventricle

dilated cardiomyopathy ( J:98940 )

• at 10-12 weeks of age had increased left-ventricular end-diastolic diameter and reduced fractional shortening indicating dilated cardiomyopathy with a depressed systolic function

decreased heart left ventricle muscle contractility ( J:98940 )

• at 10-12 weeks of age had increased left-ventricular end-diastolic diameter and reduced fractional shortening

abnormal systemic arterial blood pressure ( J:98940 )

hypertension ( J:98940 )

increased systemic arterial diastolic blood pressure ( J:98940 )

increased systemic arterial systolic blood pressure ( J:98940 )

muscle

increased myocardial fiber size ( J:98940 )

• increased cardiomyocyte area

dilated cardiomyopathy ( J:98940 )

• at 10-12 weeks of age had increased left-ventricular end-diastolic diameter and reduced fractional shortening indicating dilated cardiomyopathy with a depressed systolic function

decreased heart left ventricle muscle contractility ( J:98940 )

• at 10-12 weeks of age had increased left-ventricular end-diastolic diameter and reduced fractional shortening