Phenotypes associated with this allele

• Allele Symbol: Ighm^tm1(Bcl6)Rdf
• Allele Name: targeted mutation 1, Riccardo Dalla-Favera
• Allele ID: MGI:3581517
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Atmin^tm1.1Jhh/Atmin^tm1.1Jhh Ighm^tm1(Bcl6)Rdf/Ighm^+ Tg(Fcer2a-cre)5Mbu/0	B6.Cg-Atmin^tm1.1Jhh Ighm^tm1(Bcl6)Rdf Tg(Fcer2a-cre)5Mbu	MGI:5755471
cx2	Bcl6^tm2Rdf/Bcl6^tm2Rdf Ighm^tm1(Bcl6)Rdf/?	involves: 129/Sv * 129S1/Sv * C57BL/6	MGI:3582785
ot3	Ighm^tm1(Bcl6)Rdf/?	involves: 129/Sv * C57BL/6	MGI:3582784

Genotype
MGI:5755471

cn1

• Allelic Composition: Atmin^tm1.1Jhh/Atmin^tm1.1Jhh; Ighm^tm1(Bcl6)Rdf/Ighm⁺; Tg(Fcer2a-cre)5Mbu/0
• Genetic Background: B6.Cg-Atmin^tm1.1Jhh Ighm^tm1(Bcl6)Rdf Tg(Fcer2a-cre)5Mbu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

abnormal tumor susceptibility ( J:230105 )

• mice exhibit similar tumorigenesis as Atmin^tm1.1Jhh/Atmin^tm1.1Jhh Tg(Fcer2a-cre)5Mbu mice

Genotype
MGI:3582785

cx2

• Allelic Composition: Bcl6^tm2Rdf/Bcl6^tm2Rdf; Ighm^tm1(Bcl6)Rdf/?
• Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6

immune system

abnormal immune system morphology ( J:98937 )

• Igh-6^tm1(Bcl6)Rdf was unable to rescue the inflammatory phenotype observed in homozygous Bcl6 null mice

abnormal spleen germinal center morphology ( J:98937 )

• although proliferation of B cells expressing germinal center markers was induced, the cells did not aggregate in typical germinal center structures

hematopoietic system

abnormal spleen germinal center morphology ( J:98937 )

• although proliferation of B cells expressing germinal center markers was induced, the cells did not aggregate in typical germinal center structures

Genotype
MGI:3582784

ot3

• Allelic Composition: Ighm^tm1(Bcl6)Rdf/?
• Genetic Background: involves: 129/Sv * C57BL/6

mortality/aging

premature death ( J:98937 )

• showed increased mortality at about 13 months of age and only about 80% survived at 15 months

immune system

abnormal B cell proliferation ( J:98937 )

• 42% exhibited abnormal B cell expansions involving predominately the spleen but also the lymph nodes compared to 11% in wild-type and displayed features of benign lymphoproliferative disease

decreased plasma cell number ( J:98937 )

• about a 30% reduction in the number of total plasmacytoid cells (B220+/- CD138+), mainly due to a decrease in post-CSR plasma cells (IgM-IgD-), while IgM+IgD+ plasma cells were normal

abnormal spleen morphology ( J:98937 )

• 17% displayed a complete effacement of the splenic lymphoid architecture due to the proliferation of large lymphoid cells

enlarged spleen ( J:98937 )

• 17% exhibited a modest splenomegaly at 6 months of age

abnormal spleen B cell follicle morphology ( J:98937 )

• partial effacement of the follicular architecture with the appearance of blast cells

increased spleen germinal center number ( J:98937 )

• nonimmunized mutant mice displayed an increased number of germinal centers, comparable to that observed upon immunization in wild-type mice, and the increase in the number of germinal centers and an increase in the total germinal center area persisted after immunization

increased spleen white pulp amount ( J:98937 )

• expanded white pulp composed predominately of B cells, but also included disorganized accumulations of other cell types such as T cells and dendritic cells

decreased immunoglobulin level ( J:98937 )

• displayed a small (20-50%) reduction in total serum immunoglobulin levels of all subclasses, except for IgM, both under basal conditions and after immunization with T-dependent antigens

neoplasm

increased B cell derived lymphoma incidence ( J:98937 )

• between 15 and 20 months, 36-62% developed clonal B cell lymphomas, predominately of splenic orgin, with or without nodal involvement

• tumors displayed a mature B cell phenotype and most were histologically reminiscent of human diffuse large B cell lymphomas and contained clonal karyotypic aberrations

hematopoietic system

abnormal B cell proliferation ( J:98937 )

• 42% exhibited abnormal B cell expansions involving predominately the spleen but also the lymph nodes compared to 11% in wild-type and displayed features of benign lymphoproliferative disease

decreased plasma cell number ( J:98937 )

• about a 30% reduction in the number of total plasmacytoid cells (B220+/- CD138+), mainly due to a decrease in post-CSR plasma cells (IgM-IgD-), while IgM+IgD+ plasma cells were normal

abnormal spleen morphology ( J:98937 )

• 17% displayed a complete effacement of the splenic lymphoid architecture due to the proliferation of large lymphoid cells

enlarged spleen ( J:98937 )

• 17% exhibited a modest splenomegaly at 6 months of age

abnormal spleen B cell follicle morphology ( J:98937 )

• partial effacement of the follicular architecture with the appearance of blast cells

increased spleen germinal center number ( J:98937 )

• nonimmunized mutant mice displayed an increased number of germinal centers, comparable to that observed upon immunization in wild-type mice, and the increase in the number of germinal centers and an increase in the total germinal center area persisted after immunization

increased spleen white pulp amount ( J:98937 )

• expanded white pulp composed predominately of B cells, but also included disorganized accumulations of other cell types such as T cells and dendritic cells

decreased immunoglobulin level ( J:98937 )

• displayed a small (20-50%) reduction in total serum immunoglobulin levels of all subclasses, except for IgM, both under basal conditions and after immunization with T-dependent antigens

growth/size/body

enlarged spleen ( J:98937 )

• 17% exhibited a modest splenomegaly at 6 months of age

cellular

abnormal B cell proliferation ( J:98937 )

• 42% exhibited abnormal B cell expansions involving predominately the spleen but also the lymph nodes compared to 11% in wild-type and displayed features of benign lymphoproliferative disease

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
non-Hodgkin lymphoma		DOID:0060060	OMIM:605027	J:98937