All Phenotypes Bcl2l1<tm1Ywh> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Bcl2l1^tm1Ywh/Bcl2l1^tm1Ywh Tg(Lck-cre)548Jxm/?	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA	MGI:3582307
cn2	Bcl2l1^tm1Ywh/Bcl2l1^tm1Ywh Mcl1^tm1Ywh/Mcl1^tm1Ywh Tg(Cd4-cre)1Cwi/0	involves: 129S6/SvEvTac * C57BL/6 * DBA/2	MGI:3801468

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased thymocyte number ( J:99012 )

• homozygous mice that are also hemizygous or homozygous mice for Tg(Lck-cre)548Jxm, in which cre recombinase is active in T cell lineage, display: total thymic cellularity was reduced by 40-50%

• the number of mature CD4 positive and CD8 positive T lymphocytes in the spleen was reduced by 40-50%

• however, mutant has a normal CD4- positive and CD8-positive effector and memory T cell development

decreased double-positive T cell number ( J:99012 )

• after 1-2 days of culture, the number of cells in the double-positive compartment were dramatically reduced

hematopoietic system

decreased thymocyte number ( J:99012 )

• homozygous mice that are also hemizygous or homozygous mice for Tg(Lck-cre)548Jxm, in which cre recombinase is active in T cell lineage, display: total thymic cellularity was reduced by 40-50%

• the number of mature CD4 positive and CD8 positive T lymphocytes in the spleen was reduced by 40-50%

• however, mutant has a normal CD4- positive and CD8-positive effector and memory T cell development

decreased double-positive T cell number ( J:99012 )

• after 1-2 days of culture, the number of cells in the double-positive compartment were dramatically reduced

endocrine/exocrine glands

decreased thymocyte number ( J:99012 )

• homozygous mice that are also hemizygous or homozygous mice for Tg(Lck-cre)548Jxm, in which cre recombinase is active in T cell lineage, display: total thymic cellularity was reduced by 40-50%

• the number of mature CD4 positive and CD8 positive T lymphocytes in the spleen was reduced by 40-50%

• however, mutant has a normal CD4- positive and CD8-positive effector and memory T cell development

Allelic Composition	Bcl2l1^tm1Ywh/Bcl2l1^tm1Ywh Mcl1^tm1Ywh/Mcl1^tm1Ywh Tg(Cd4-cre)1Cwi/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1^tm1Ywh mutation (0 available); any Bcl2l1 mutation (104 available)
Mcl1^tm1Ywh mutation (0 available); any Mcl1 mutation (35 available)
Tg(Cd4-cre)1Cwi mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased double-positive T cell number ( J:137400 )

• the frequency of double positive T cells is reduced to 45% of thymocytes compared to 85% in wild-type mice

• the absolute number of double positive cells is 10% of wild-type

absent CD4-positive, alpha-beta T cells ( J:137400 )

absent CD8-positive, alpha-beta T cells ( J:137400 )

hematopoietic system

decreased double-positive T cell number ( J:137400 )

• the frequency of double positive T cells is reduced to 45% of thymocytes compared to 85% in wild-type mice

• the absolute number of double positive cells is 10% of wild-type

absent CD4-positive, alpha-beta T cells ( J:137400 )

absent CD8-positive, alpha-beta T cells ( J:137400 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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