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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Chrm4tm1Minm
targeted mutation 1, Minoru Matsui
MGI:3581713
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Chrm4tm1Minm/Chrm4tm1Minm involves: 129X1/SvJ * DBA/2J MGI:3581736


Genotype
MGI:3581736
hm1
Allelic
Composition		 Chrm4tm1Minm/Chrm4tm1Minm
Genetic
Background		 involves: 129X1/SvJ * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrm4tm1Minm mutation (0 available); any Chrm4 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal behavioral response to xenobiotic ( J:99248 )
• scopolamine, a muscarinic receptor antagonist, could not suppress haloperidol-induced catalepsy as it did in wild-type controls
abnormal locomotor behavior ( J:99248 )
• basal locomotor activity was not different from wildtype, however the enhancement of locomotor activity by a D1 receptor-selective agonist was significantly stronger than in controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory