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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Chrm2tm1Minm
targeted mutation 1, Minoru Matsui
MGI:3581741
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Chrm2tm1Minm/Chrm2tm1Minm involves: 129X1/SvJ * C57BL/6 MGI:3581815
cx2
 		Chrm2tm1Minm/Chrm2tm1Minm
Chrm3tm1Mmt/Chrm3tm1Mmt 		involves: 129X1/SvJ * C57BL/6 MGI:3581821


Genotype
MGI:3581815
hm1
Allelic
Composition		 Chrm2tm1Minm/Chrm2tm1Minm
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrm2tm1Minm mutation (0 available); any Chrm2 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal/urinary system phenotype ( J:99247 )
N
• normal urinary bladder

muscle
muscle phenotype ( J:99247 )
N
• normal smooth muscle contraction in response to carbachol

vision/eye
vision/eye phenotype ( J:99247 )
N
• normal pupil size




Genotype
MGI:3581821
cx2
Allelic
Composition		 Chrm2tm1Minm/Chrm2tm1Minm
Chrm3tm1Mmt/Chrm3tm1Mmt
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrm2tm1Minm mutation (0 available); any Chrm2 mutation (32 available)
Chrm3tm1Mmt mutation (0 available); any Chrm3 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
postnatal growth retardation ( J:99247 )
• transient postweaning growth retardation, which is improved by feeding with paste food

muscle
impaired smooth muscle contractility ( J:99247 )
• bladder and ileal smooth muscle do not respond to carbachol, even at concentrations that evoke maximal cholinergic contractions in wild-type
• noncholinergic contraction elicited by electrical field stimulation is significantly weaker when male bladder strips are stimulated at 1 or 10 Hz and is significantly larger when male ileum is stimulated at 1 Hz but not 10 Hz compared to wild-type
• noncholinergic contraction elicited by electrical field stimulation is significantly larger when female bladder strips are stimulated at 1 Hz but not 10 Hz and when female ileum is stimulated at 10 Hz but not 1 Hz compared to wild-type
impaired contractility of ileal smooth muscle ( J:99247 )
• ileal smooth muscle does not respond to carbachol, even at concentrations that evoke maximal cholinergic contractions in wild-type

renal/urinary system
distended urinary bladder ( J:99247 )
• seen only in males and no different from single homozygous Chrm3 mutant mice, however digestive tract, heart, lung and spleen were normal

vision/eye
mydriasis ( J:99247 )
• partially dilated pupils, however they are smaller than in single homozygous Chrm3 mutant mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory