Analysis Tools|
Allele Symbol Allele Name Allele ID |
Chrm2tm1Minm targeted mutation 1, Minoru Matsui MGI:3581741 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• normal urinary bladder
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| N |
• normal smooth muscle contraction in response to carbachol
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| N |
• normal pupil size
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• transient postweaning growth retardation, which is improved by feeding with paste food
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• bladder and ileal smooth muscle do not respond to carbachol, even at concentrations that evoke maximal cholinergic contractions in wild-type
• noncholinergic contraction elicited by electrical field stimulation is significantly weaker when male bladder strips are stimulated at 1 or 10 Hz and is significantly larger when male ileum is stimulated at 1 Hz but not 10 Hz compared to wild-type
• noncholinergic contraction elicited by electrical field stimulation is significantly larger when female bladder strips are stimulated at 1 Hz but not 10 Hz and when female ileum is stimulated at 10 Hz but not 1 Hz compared to wild-type
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• ileal smooth muscle does not respond to carbachol, even at concentrations that evoke maximal cholinergic contractions in wild-type
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• seen only in males and no different from single homozygous Chrm3 mutant mice, however digestive tract, heart, lung and spleen were normal
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• partially dilated pupils, however they are smaller than in single homozygous Chrm3 mutant mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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