Phenotypes associated with this allele

• Allele Symbol: Tek^tm1Ber
• Allele Name: targeted mutation 1, Alan Bernstein
• Allele ID: MGI:3581758
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tek^tm1Ber/Tek^tm1Ber	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3582527

Genotype
MGI:3582527

hm1

• Allelic Composition: Tek^tm1Ber/Tek^tm1Ber
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:99096 )

• homozygous embryos are present at E9.5 but absent at E10.5

cardiovascular system

failure of vascular branching ( J:99096 )

• vascular branching and sprouting are impaired and the complexity of the vascular network is decreased; however the number of pericytes surrounding the blood vessels is normal and no gaps are seen in the vascular endothelial cells

abnormal vitelline vasculature morphology ( J:99096 )

• at E9.5 the vitteline vasculature fails to reorganize into a mature branched network; however, the immature plexus forms normally

absent myocardial trabeculae ( J:99096 )

• absent myocardial trabeculations at E9.5

abnormal heart development ( J:99096 )

• at E9.5 the endothelium lining the myocardium is less intricately folded and the endocardial lining appears collapsed and retracted from the myocardial wall

embryo

abnormal vitelline vasculature morphology ( J:99096 )

• at E9.5 the vitteline vasculature fails to reorganize into a mature branched network; however, the immature plexus forms normally

hematopoietic system

abnormal definitive hematopoiesis ( J:99096 )

• multilineage hematopoietic stem cell clusters in the omphalomesenteric and vitelline arteries are absent and the number of hematopoietic cells produced in vitro is severely reduced

muscle

absent myocardial trabeculae ( J:99096 )

• absent myocardial trabeculations at E9.5