Phenotypes associated with this allele

• Allele Symbol: Cd207^tm2.1Mal
• Allele Name: targeted mutation 1.1, Bernard Malissen
• Allele ID: MGI:3581825
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Cd207^tm2.1Mal/Cd207^tm3.1(HBEGF/EGFP)Mal	involves: 129S2/SvPas	MGI:3582567

Genotype
MGI:3582567

ht1

• Allelic Composition: Cd207^tm2.1Mal/Cd207^{tm3.1(HBEGF/EGFP)Mal}
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal Langerhans cell morphology ( J:99114 )

• no effect of diphtheria toxin-induced Langerhans cell depletion was seen on dinitrofluorobenzene-induced skin contact hypersensitivity

decreased Langerhans cell number ( J:99114 )

• injection of 1 ug of diphtheria toxin results in 93% and 70% reduction in the number of Langerhans cell derived dendritic cells and CD8alpha+ dendritic cells in the cutaneous lymph nodes

absent Langerhans cell ( J:99114 )

• intraperitoneal injection of 100 ng of diphtheria toxin results in complete elimination of epidermal Langerhans cell by 24 hours after treatment, this persisted for 6-7 days and complete recovery was seen around 14 days after treatment

hematopoietic system

abnormal Langerhans cell morphology ( J:99114 )

• no effect of diphtheria toxin-induced Langerhans cell depletion was seen on dinitrofluorobenzene-induced skin contact hypersensitivity

decreased Langerhans cell number ( J:99114 )

• injection of 1 ug of diphtheria toxin results in 93% and 70% reduction in the number of Langerhans cell derived dendritic cells and CD8alpha+ dendritic cells in the cutaneous lymph nodes

absent Langerhans cell ( J:99114 )

• intraperitoneal injection of 100 ng of diphtheria toxin results in complete elimination of epidermal Langerhans cell by 24 hours after treatment, this persisted for 6-7 days and complete recovery was seen around 14 days after treatment