Phenotypes associated with this allele

• Allele Symbol: Rac3^tm1Idc
• Allele Name: targeted mutation 1, Ivan de Curtis
• Allele ID: MGI:3581887
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rac3^tm1Idc/Rac3^tm1Idc	either: (involves: 129S1/Sv * 129S2/SvPasIco * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)	MGI:3582341

Genotype
MGI:3582341

hm1

• Allelic Composition: Rac3^tm1Idc/Rac3^tm1Idc
• Genetic Background: either: (involves: 129S1/Sv * 129S2/SvPasIco * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal motor learning ( J:99180 )

• homozygotes have improved performance in later trials on the accelerating rotarod at 6 weeks of age and the same animals showed improved performance in all trials when retested at 15 weeks of age

short stride length ( J:99180 )

• the left and right stride lengths are decreased by 12%; however, the sciatic nerve appears normal

increased thermal nociceptive threshold ( J:99180 )

• latency to first paw lick is increased an average of 60% compared to wild-type mice; however the latency to jump is not increased

nervous system

nervous system phenotype ( J:99180 )

N • gross morphology and macroscopic development of the brain and the general organization of neurites and synapses are normal