Phenotypes associated with this allele

• Allele Symbol: Spint1^tm1Hk
• Allele Name: targeted mutation 1, Hiroaki Kataoka
• Allele ID: MGI:3581891
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Spint1^tm1Hk/Spint1^tm1Hk	involves: C57BL/6 * CBA	MGI:3582348

Genotype
MGI:3582348

hm1

• Allelic Composition: Spint1^tm1Hk/Spint1^tm1Hk
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:99182 )

• some dead and degenerating embryos are seen at E10.5, by E11.5 all embryos are dead

embryo

increased embryonic tissue cell apoptosis ( J:99182 )

• massive apoptosis in E10.5 embryos

embryonic growth arrest ( J:99182 )

• growth retardation was occasionally observed at E9.5, and was evident at E10, with E10 embryos resembling wildtype embryos at E9.5

abnormal placenta morphology ( J:99182 )

abnormal placenta vasculature ( J:99182 )

• branching of fetal vessels in the placenta was insufficient compared to controls at E8.5 and fetal vessels failed to elongate and bifurcate into the labyrinth layer and instead collapsed and some showed degenerative change and thrombus formation at E11.5

abnormal trophoblast giant cell morphology ( J:99182 )

• chorionic trophoblasts were packed and did not show migration and differentiation to form the labyrinth layer

abnormal chorionic plate morphology ( J:99182 )

• chorionic plate was thin at E8.5

absent placental labyrinth ( J:99182 )

• differentiated labyrinthine trophoblasts were absent at E10.5 and an organized labyrinth layer failed to form at E11.5, however the spongiotrophoblast and giant cell layers and the yolk sac appeared normal

abnormal placenta development ( J:99182 )

abnormal placental transport ( J:99182 )

• impaired placental transport function, as indicated by decreased passive passage of dye from the mother to the embryo and decreased elimination of dye from embryo circulation

cellular

increased embryonic tissue cell apoptosis ( J:99182 )

• massive apoptosis in E10.5 embryos

cardiovascular system

abnormal placenta vasculature ( J:99182 )

• branching of fetal vessels in the placenta was insufficient compared to controls at E8.5 and fetal vessels failed to elongate and bifurcate into the labyrinth layer and instead collapsed and some showed degenerative change and thrombus formation at E11.5

enlarged pericardium ( J:99182 )

• seen in E10.5 embryos