Analysis Tools
growth/size/body
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• females displayed significant growth retardation postnatally from 8 weeks onward
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homeostasis/metabolism
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• almost no acute insulin secretion in response to elevated blood glucose levels and pancreatic islets did not secrete insulin in response to glucose, arginine, or KCl stimulation in vitro
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• significantly higher fasting blood glucose levels in females at 4 weeks of age, and both males and females had high blood glucose levels at 8 weeks of age
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• significantly lower plasma insulin levels after glucose injection (0.51 ng/ml vs 1.51 ng/ml in wild-type) or arginine administration
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• significantly higher blood glucose levels than wild-type in a glucose tolerance test
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• 5/19 adult males became urinary glucose positive by 20 weeks of age
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endocrine/exocrine glands
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• significant difference in the structure of islets and the ratio of beta to alpha cells at 12 weeks of age but not at P1
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• almost no acute insulin secretion in response to elevated blood glucose levels and pancreatic islets did not secrete insulin in response to glucose, arginine, or KCl stimulation in vitro
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renal/urinary system
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• 5/19 adult males became urinary glucose positive by 20 weeks of age
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| maturity-onset diabetes of the young | DOID:0050524 |
OMIM:606391 |
J:99126 | |
| type 2 diabetes mellitus | DOID:9352 |
OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036 |
J:99126 | |
