Phenotypes associated with this allele

• Allele Symbol: Thbs3^tm1Bst
• Allele Name: targeted mutation 1, Paul Bornstein
• Allele ID: MGI:3581964
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Thbs3^tm1Bst/Thbs3^tm1Bst	involves: 129X1/SvJ * C57BL/6	MGI:3582362

Genotype
MGI:3582362

hm1

• Allelic Composition: Thbs3^tm1Bst/Thbs3^tm1Bst
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased body weight ( J:99120 )

• both males and females were significantly heavier at 9 weeks of age, but this difference was no longer apparent at 15 weeks of age

skeleton

abnormal femur morphology ( J:99120 )

• femurs show increased periosteal and endocortical diameters and greater moments of inertia in 9 and 15 week old males and in 9 week old females, with these differences no longer detected in older mice

• increased cortical area in 9 week old males

• femurs show increased bending strength and failure loads at 9, but not 15, weeks of age

premature bone ossification ( J:99120 )

• femoral heads ossify earlier than in wild-type, as evidenced by a trabecular bone pattern at 9 and 15 weeks of age that was not observed in wild-type at this age

limbs/digits/tail

abnormal femur morphology ( J:99120 )

• femurs show increased periosteal and endocortical diameters and greater moments of inertia in 9 and 15 week old males and in 9 week old females, with these differences no longer detected in older mice

• increased cortical area in 9 week old males

• femurs show increased bending strength and failure loads at 9, but not 15, weeks of age