Analysis Tools
cellular
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• only 61% of fertilized eggs from superovulated homozygous null females progressed to the eight-cell stage compared to 94% of wild-type and this effect was exacerbated, as most eggs arrested at the one-cell stage, after activation of the interferon/Oas1a/Rnase L pathway by poly(I-C)
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reproductive system
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• fewer corpora lutea at 12 weeks of age
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• contained more degenerating follicles than in wild-type
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• fewer eggs were released when females were superovulated with exogenous gonadotropins and mated with males and this effect was exacerbated after activation of the interferon/Oas1a/Rnase L pathway by poly(I-C)
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• homozygous null females bred to wild-type males over a 6 month period displayed reduced fertility, with fewer pups born in each litter and reduced litters per month
• however, males displayed normal fertility
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• homozygous null females bred to wild-type males over a 6 month period produced fewer pups in each litter and reduced litters per month
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endocrine/exocrine glands
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• fewer corpora lutea at 12 weeks of age
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• contained more degenerating follicles than in wild-type
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