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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Tcra,Tcrb)1Mcd
transgene insertion 1, Hugh O McDevitt
MGI:3581980
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Tg(LCK-NFKBIA)5Dwb/?
Tg(Tcra,Tcrb)1Mcd/? 		involves: BALB/c * C57BL/6 * DBA/2 MGI:3835055


Genotype
MGI:3835055
cx1
Allelic
Composition		 Tg(LCK-NFKBIA)5Dwb/?
Tg(Tcra,Tcrb)1Mcd/?
Genetic
Background		 involves: BALB/c * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(LCK-NFKBIA)5Dwb mutation (2 available)
Tg(Tcra,Tcrb)1Mcd mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interferon-gamma secretion ( J:145531 )
• mutant T cells produce very little IFN-gamma when transferred into host that is immunized with hemagglutinin




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory