All Phenotypes Eif2ak4<tm1.2Dron> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Eif2ak4^tm1.2Dron
targeted mutation 1.2, David Ron
MGI:3582154

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Eif2ak4^tm1.2Dron/Eif2ak4^tm1.2Dron	129S6/SvEvTac-Eif2ak4^tm1.2Dron	MGI:3804304
hm2	Eif2ak4^tm1.2Dron/Eif2ak4^tm1.2Dron	involves: 129S6/SvEvTac	MGI:3806279
hm3	Eif2ak4^tm1.2Dron/Eif2ak4^tm1.2Dron	involves: 129S6/SvEvTac * C57BL/6 * CBA	MGI:3709836

Allelic Composition	Eif2ak4^tm1.2Dron/Eif2ak4^tm1.2Dron
Genetic Background	129S6/SvEvTac-Eif2ak4^tm1.2Dron

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif2ak4^tm1.2Dron mutation (3 available); any Eif2ak4 mutation (89 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal contextual conditioning behavior ( J:100646 )

• homozygotes display impaired contextual fear conditioning but normal auditory fear conditioning

abnormal spatial reference memory ( J:100646 )

• homozygotes display impaired hippocampus-dependent spatial memory in a Morris water maze with repeated trials (strong conditioning) but improved spatial memory with a single trial (weak conditioning)

nervous system

abnormal long-term potentiation ( J:100646 )

• a single tetanus induces a robust and sustained late LTP unlike in wild-type mice where a single tetanus induces early LTP

• after repeated tetanic stimulation (4 trains at 100 Hz) the duration of late LTP is reduced, returning to baseline within 3 hours

Allelic Composition	Eif2ak4^tm1.2Dron/Eif2ak4^tm1.2Dron
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif2ak4^tm1.2Dron mutation (3 available); any Eif2ak4 mutation (89 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal food preference ( J:129841 )

• mice have much less of an aversion to diets lacking an essential amino acid

• mice consume 7.7% less leucine-deficient chow after 1 hour compared to wild-type mice that consume 28.8% less

• mice consume 9.4% less leucine-deficient chow after 4 hours compared to wild-type mice that consume 34.1% less

• similar responses are observed in threonine-deficient diet

Allelic Composition	Eif2ak4^tm1.2Dron/Eif2ak4^tm1.2Dron
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif2ak4^tm1.2Dron mutation (3 available); any Eif2ak4 mutation (89 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal dendritic cell physiology ( J:120813 )

• splenic CD19+ dendritic cells treated with CTLA4-immunoglobulin do not produce IFNalpha, indicating a defect in response to CD80/86 (B7) ligation; production induced by TLR9 stimulation is equivalent to that in wild-type

abnormal cytokine secretion ( J:120813 )

• splenic CD19+ dendritic cells do not secrete IFNalpha upon CTLA4-Ig treatement

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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