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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adgre1tm1Stst
targeted mutation 1, Joan Stein-Streilein
MGI:3582333
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Adgre1tm1Stst/Adgre1tm1Stst B6.129S1-Emr1tm1Stst MGI:3582731


Genotype
MGI:3582731
hm1
Allelic
Composition		 Adgre1tm1Stst/Adgre1tm1Stst
Genetic
Background		 B6.129S1-Emr1tm1Stst
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgre1tm1Stst mutation (2 available); any Adgre1 mutation (79 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal regulatory T cell physiology ( J:99213 )
• in a low-dose oral tolerance model, homozygous null mice were not able to generate an efferent CD+ T reg cell population that suppressed an antigen-specific DTH response
abnormal immune tolerance ( J:99213 )
• in the anterior chamber-associated immune deviation (ACAID) model of peripheral tolerance, anterior chamber inoculation of antigen was unable to induce efferent regulatory T (T reg) cells and suppress delayed-type hypersensitivity (DTH) responses

hematopoietic system
abnormal regulatory T cell physiology ( J:99213 )
• in a low-dose oral tolerance model, homozygous null mice were not able to generate an efferent CD+ T reg cell population that suppressed an antigen-specific DTH response




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory