Analysis Tools
mortality/aging
|
• homozygotes bearing injected with CT26 colon tumor cells die sooner compared to wild-type mice
|
immune system
|
• under Th1-generating conditions T cells cultured with mutant bone marrow-derived dendritic cells produce 40% fewer IFNG+ cells; however no difference in proliferation was seen under Th2-generating conditions
• expansion of adoptively transferred naive D011.10 CD4 T cells is reduced in the spleen (by 34%), peripheral lymph nodes (50%), hepatic lymph nodes (42%), and liver (61%)
• however; overall cell numbers and proportions of T, B, natural killer, natural killer T, and dendritic cells in the thymus and spleen and cell yield from bone marrow-derived dendritic cell cultures are similar to wild-type
|
|
• homozygous null mice immunized with a T cell dependent antigen produced significantly less IgG2a
|
|
• cytotoxic T cell activity is reduced by about 50% in homozygous mice immunized with hemagglutinin-specific CD8 T cells then injected with BALB/c splenocytes loaded with hemagglutinin compared to wild-type mice treated in the same way
|
|
• significantly less IFNG and IL-2 and more IL-4 are produced in homozygotes immunized with peptide-pulsed homozygous bone marrow-derived dendritic cells compared to wild-type mice immunized with peptide pulsed wild-type bone marrow-derived dendritic cells
|
neoplasm
|
• CT26 tumor cell-derived hepatic tumors grow more rapidly
|
hematopoietic system
|
• under Th1-generating conditions T cells cultured with mutant bone marrow-derived dendritic cells produce 40% fewer IFNG+ cells; however no difference in proliferation was seen under Th2-generating conditions
• expansion of adoptively transferred naive D011.10 CD4 T cells is reduced in the spleen (by 34%), peripheral lymph nodes (50%), hepatic lymph nodes (42%), and liver (61%)
• however; overall cell numbers and proportions of T, B, natural killer, natural killer T, and dendritic cells in the thymus and spleen and cell yield from bone marrow-derived dendritic cell cultures are similar to wild-type
|
|
• homozygous null mice immunized with a T cell dependent antigen produced significantly less IgG2a
|
|
• cytotoxic T cell activity is reduced by about 50% in homozygous mice immunized with hemagglutinin-specific CD8 T cells then injected with BALB/c splenocytes loaded with hemagglutinin compared to wild-type mice treated in the same way
|
cellular
|
• under Th1-generating conditions T cells cultured with mutant bone marrow-derived dendritic cells produce 40% fewer IFNG+ cells; however no difference in proliferation was seen under Th2-generating conditions
• expansion of adoptively transferred naive D011.10 CD4 T cells is reduced in the spleen (by 34%), peripheral lymph nodes (50%), hepatic lymph nodes (42%), and liver (61%)
• however; overall cell numbers and proportions of T, B, natural killer, natural killer T, and dendritic cells in the thymus and spleen and cell yield from bone marrow-derived dendritic cell cultures are similar to wild-type
|
