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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ighmtm1Sls
targeted mutation 1, Erik Selsing
MGI:3582575
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ighmtm1Sls/Ighmtm1Sls Not Specified MGI:3602998


Genotype
MGI:3602998
hm1
Allelic
Composition		 Ighmtm1Sls/Ighmtm1Sls
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighmtm1Sls mutation (0 available); any Ighm mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal class switch recombination ( J:99465 )
• class switching is partially reduced for all IgG isotypes
decreased IgG level ( J:99465 )
• serum levels of IgG1 an IgG3 are slightly reduced and a large reduction is seen in levels of IgG2b
• levels of IgA are normal
increased IgM level ( J:99465 )
• serum levels of IgM are increased but surface levels on splenocytes and numbers of IgM expressing B cells are similar to wild-type

hematopoietic system
abnormal class switch recombination ( J:99465 )
• class switching is partially reduced for all IgG isotypes
decreased IgG level ( J:99465 )
• serum levels of IgG1 an IgG3 are slightly reduced and a large reduction is seen in levels of IgG2b
• levels of IgA are normal
increased IgM level ( J:99465 )
• serum levels of IgM are increased but surface levels on splenocytes and numbers of IgM expressing B cells are similar to wild-type




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory