Analysis Tools
digestive/alimentary system
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• the striated ducts cells lack characteristic cytoplasmic granules
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• at 3 - 6 weeks of age a marked loss of differentiation of the epithelium in gastric glands is seen with loss of chief cells
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• at 3 - 6 weeks of age a marked loss of differentiation of the epithelium in gastric glands is seen with severely decreased numbers of parietal cells
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• at 3 - 6 weeks of age a marked loss of differentiation of the epithelium in gastric glands is seen with loss of chief cells, severely decreased numbers of parietal cells and presence of abnormal mucoid-containing cells
• at 40 weeks of age in most of the stomach fundus the epithelium of the gastric glands displays cellular crowding, nuclear pleomorphism, increased nuclear to cytoplasmic ratio, and loss of nuclear polarity
• at 40 weeks of age in some portions of the stomach fundus gastric glands resemble pyloric-like glands with numerous mucoid-containing cells
• however, no malformations or functional defects were detected in the tight junctions of the intestinal epithelium
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• by 40 weeks of age the mucosa appears thickened
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• gastritis is seen around 10 weeks of age and becomes severe by 28 weeks of age
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immune system
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• gastritis is seen around 10 weeks of age and becomes severe by 28 weeks of age
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endocrine/exocrine glands
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• the striated ducts cells lack characteristic cytoplasmic granules
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• at 3 - 6 weeks of age a marked loss of differentiation of the epithelium in gastric glands is seen with loss of chief cells
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• at 3 - 6 weeks of age a marked loss of differentiation of the epithelium in gastric glands is seen with severely decreased numbers of parietal cells
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• at 40 - 60 weeks of age atrophy of the seminiferous tubules is seen with atrophied tubules being devoid of germ cells
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growth/size/body
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• after birth the body weights of homozygotes begins to lag behind wild-type mice and by 8 weeks of age male and female homozygotes are 72% and 77% of normal weight, respectively
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behavior/neurological
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• females do not suckle their litters
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reproductive system
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• at 40 - 60 weeks of age atrophy of the seminiferous tubules is seen with atrophied tubules being devoid of germ cells
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• males but not females are infertile
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nervous system
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• progressive accumulation of mineral deposits is seen beginning at 9 weeks of age resulting in concentric, often laminated deposits
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• progressive accumulation of mineral deposits is seen beginning at 9 weeks of age resulting in concentric, often laminated deposits
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limbs/digits/tail
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• compact bone layer is significantly thinner
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skeleton
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• compact bone layer is significantly thinner
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homeostasis/metabolism
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• despite calcification in the brain and thinning of compact bone in the femur serum and urine levels of calcium and phosphate are normal
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