Phenotypes associated with this allele

• Allele Symbol: Cyp11b2^tm1Hsk
• Allele Name: targeted mutation 1, Hyung-Suk Kim
• Allele ID: MGI:3582593
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cyp11b2^tm1Hsk/Cyp11b2^tm1Hsk	involves: 129S6/SvEvTac	MGI:3582986

Genotype
MGI:3582986

hm1

• Allelic Composition: Cyp11b2^tm1Hsk/Cyp11b2^tm1Hsk
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:99269 )

• 30% die between day 7 and 28

growth/size/body

decreased body weight ( J:99269 )

• adult weight is 75% of wild-type

homeostasis/metabolism

increased circulating angiotensin II level ( J:99269 )

• plasma concentration of Ang II is increased ~4-fold

increased circulating corticosterone level ( J:99269 )

• plasma concentration of corticosterone 79.0 +/- 11.0 versus 51.2 +/- 11.1 ng/ml in wild-type

decreased circulating aldosterone level ( J:99269 )

• aldosterone was undetectable in plasma

increased circulating potassium level ( J:99269 )

• plasma K+ concentration 6.1 +/- 0.1 versus 5.2+/- 0.1 mM in wild-type

increased circulating renin level ( J:99269 )

• plasma renin is 45x higher than in wild-type

decreased circulating chloride level ( J:99269 )

• plasma Cl- concentration 128.8 +/- 0.6 versus 133.1 +/- 0.6 mM in wild-type

increased renin activity ( J:99269 )

cardiovascular system

hypotension ( J:99269 )

• mild hypotension 111.7 versus 97.3 mM Hg in wild-type

endocrine/exocrine glands

abnormal adrenal cortex morphology ( J:99269 )

• adrenal cortex is disorganized and glomerulosa is thickened

• Oil-Red-O staining shows lipid levels are 3x wild-type

abnormal adrenal gland zona glomerulosa morphology ( J:99269 )

• zona glomerulosa is widened and includes easily detectable renin-containing cells

abnormal adrenocortical cell morphology ( J:99269 )

• adrenal cortex cells appear foamy, and have a vacuolated cytoplasm and abnormal shapes