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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gata1tm7Sho
targeted mutation 7, Stuart H Orkin
MGI:3582677
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gata1tm7Sho/Gata1tm7Sho involves: 129S1/Sv * C57BL/6 MGI:3582839
ot2
 		Gata1tm7Sho/Y involves: 129S1/Sv * C57BL/6 MGI:3582858


Genotype
MGI:3582839
hm1
Allelic
Composition		 Gata1tm7Sho/Gata1tm7Sho
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1tm7Sho mutation (0 available); any Gata1 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
liver hypoplasia ( J:99310 )
• fetal liver cellularity was reduced by approximately 50% at E12.5
• fetal liver cellularity normal at E14.5 and later
pale liver ( J:99310 )
• liver pallor exhibited at E12.5

hematopoietic system
abnormal erythropoiesis ( J:99310 )
• transient embryonic erythropoiesis impairment
abnormal megakaryocyte progenitor cell morphology ( J:99310 )
• colony assays revealed midgestation fetal liver megakaryocyte progenitors formed numerous macroscopic abnormal megakaryocyte colony-forming units
• transient (E9.5-E11.5) hyperproliferative yolk sac megakaryocyte colony-forming units observed by colony assay
• transient (E11.5-E14.5) hyperproliferative fetal liver megakaryocyte colony-forming units observed by colony assay




Genotype
MGI:3582858
ot2
Allelic
Composition		 Gata1tm7Sho/Y
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1tm7Sho mutation (0 available); any Gata1 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
liver hypoplasia ( J:99310 )
• fetal liver cellularity was reduced by approximately 50% at E12.5
• fetal liver cellularity normal at E14.5 and later
pale liver ( J:99310 )
• liver pallor exhibited at E12.5

hematopoietic system
abnormal erythropoiesis ( J:99310 )
• transient embryonic erythropoiesis impairment
abnormal megakaryocyte progenitor cell morphology ( J:99310 )
• colony assays revealed midgestation fetal liver megakaryocyte progenitors formed numerous macroscopic abnormal megakaryocyte colony-forming units
• transient (E9.5-E11.5) hyperproliferative yolk sac megakaryocyte colony-forming units observed by colony assay
• transient (E11.5-E14.5) hyperproliferative fetal liver megakaryocyte colony-forming units observed by colony assay




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory