All Phenotypes Gata1<tm8.2Sho> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gata1^tm8.2Sho
targeted mutation 8.2, Stuart H Orkin
MGI:3582683

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gata1^tm8.2Sho/Gata1^tm8.2Sho	involves: 129S1/Sv	MGI:3716339
cx2	Dp(16Cbr1-Fam3b)1Rhr/0 Gata1^tm8.2Sho/Y	involves: 129S1/Sv * 129S6/SvEvTac	MGI:5429726
ot3	Gata1^tm8.2Sho/Y	involves: 129S1/Sv	MGI:3716338

Allelic Composition	Gata1^tm8.2Sho/Gata1^tm8.2Sho
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1^tm8.2Sho mutation (0 available); any Gata1 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

liver hypoplasia ( J:99310 )

• authors state that mice have an identical phenotype to that found in Gata1^tm7Sho homozygous females

pale liver ( J:99310 )

• authors state that mice have an identical phenotype to that found in Gata1^tm7Sho homozygous females

hematopoietic system

abnormal erythropoiesis ( J:99310 )

• authors state that mice have an identical phenotype to that found in Gata1^tm7Sho homozygous females

abnormal megakaryocyte morphology ( J:99310 )

• authors state that mice have an identical phenotype to that found in Gata1^tm7Sho homozygous females

Allelic Composition	Dp(16Cbr1-Fam3b)1Rhr/0 Gata1^tm8.2Sho/Y
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dp(16Cbr1-Fam3b)1Rhr mutation (1 available); any Dp(16Cbr1-Fam3b)1Rhr mutation (1 available)
Gata1^tm8.2Sho mutation (0 available); any Gata1 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

enlarged spleen ( J:184564 )

• in 6 month old mutants

extramedullary hematopoiesis ( J:184564 )

• extensive extramedullary hematopoiesis in 6 month old mutants

anemia ( J:184564 )

• adult mutants are mildly anemic

abnormal bone marrow cell morphology/development ( J:184564 )

• 6 month old mutants exhibit marrow fibrosis

• increase in the number of CFU-GM colonies in the bone marrow in 6 month old mutants

abnormal bone marrow cell number ( J:184564 )

• 6 month old mutants exhibit marrow fibrosis, with increased megakaryocytes present in clusters

increased megakaryocyte cell number ( J:184564 )

• increase in number of megakaryocytes in the bone marrow in 6 month old mutants

abnormal megakaryocyte progenitor cell morphology ( J:184564 )

• increase in number of CFU-Mk colonies in the bone marrow and/or spleen

thrombocytosis ( J:184564 )

• adults develop a transient thrombocytosis

increased monocyte cell number ( J:184564 )

• increase in number of monocytes in the bone marrow and/or the spleen of 6 month old mutants

immune system

enlarged spleen ( J:184564 )

• in 6 month old mutants

increased monocyte cell number ( J:184564 )

• increase in number of monocytes in the bone marrow and/or the spleen of 6 month old mutants

growth/size/body

enlarged spleen ( J:184564 )

• in 6 month old mutants

Allelic Composition	Gata1^tm8.2Sho/Y
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1^tm8.2Sho mutation (0 available); any Gata1 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

liver hypoplasia ( J:99310 )

• authors state that mice have an identical phenotype to that found in Gata1^tm7Sho heterozygous males

pale liver ( J:99310 )

• authors state that mice have an identical phenotype to that found in Gata1^tm7Sho heterozygous males

hematopoietic system

abnormal erythropoiesis ( J:99310 )

• authors state that mice have an identical phenotype to that found in Gata1^tm7Sho heterozygous males

abnormal megakaryocyte morphology ( J:99310 )

• authors state that mice have an identical phenotype to that found in Gata1^tm7Sho heterozygous males

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24