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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rec8tm1Mjm
targeted mutation 1, Michael J McKay
MGI:3583574
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rec8tm1Mjm/Rec8tm1Mjm either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * C57BL/6) MGI:3583781


Genotype
MGI:3583781
hm1
Allelic
Composition		 Rec8tm1Mjm/Rec8tm1Mjm
Genetic
Background		 either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rec8tm1Mjm mutation (1 available); any Rec8 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:99402 )
• only 12% of pups from heterozygous matings are homozygous and at E13.5 only 16% of embryos are homozygous

reproductive system
abnormal seminiferous tubule morphology ( J:99402 )
• more apoptotic cells are seen in the tubules compared to wild-type mice
abnormal female reproductive system morphology ( J:99402 )
• the genital tract is involuted
abnormal ovary morphology ( J:99402 )
• dense fibrovascular stoma is seen
absent oocytes ( J:99402 )
• complete absence of oocytes
azoospermia ( J:99402 )
• no mature sperm or spermatids are seen and testes are almost depleted of primary spemtocytes by 19 days of age
abnormal female meiosis ( J:99402 )
• homozygous meiocytes fail to complete meiotic prophase I and abnormal synaptonemal complexes form between sister chromatids rather than between homologous chromososmes
• leptotene chromosomes are seen at E16.5-E18.5 but normal pachytene nuclei are never seen
arrest of male meiosis ( J:99402 )
• homozygous meiocytes fail to complete meiotic prophase I and abnormal synaptonemal complexes form between sister chromatids rather than between homologous chromososmes
• zygotene but not pachytene nuclei are seen

growth/size/body
postnatal growth retardation ( J:99402 )
decreased fetal size ( J:99402 )
• reduced size at E15.5

endocrine/exocrine glands
abnormal ovary morphology ( J:99402 )
• dense fibrovascular stoma is seen
abnormal seminiferous tubule morphology ( J:99402 )
• more apoptotic cells are seen in the tubules compared to wild-type mice

cellular
absent oocytes ( J:99402 )
• complete absence of oocytes
azoospermia ( J:99402 )
• no mature sperm or spermatids are seen and testes are almost depleted of primary spemtocytes by 19 days of age
abnormal female meiosis ( J:99402 )
• homozygous meiocytes fail to complete meiotic prophase I and abnormal synaptonemal complexes form between sister chromatids rather than between homologous chromososmes
• leptotene chromosomes are seen at E16.5-E18.5 but normal pachytene nuclei are never seen
arrest of male meiosis ( J:99402 )
• homozygous meiocytes fail to complete meiotic prophase I and abnormal synaptonemal complexes form between sister chromatids rather than between homologous chromososmes
• zygotene but not pachytene nuclei are seen




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory