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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ddit4tm1Lwe
targeted mutation 1, Leif W Ellisen
MGI:3583650
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ddit4tm1Lwe/Ddit4tm1Lwe involves: 129S4/SvJae MGI:3583716


Genotype
MGI:3583716
hm1
Allelic
Composition		 Ddit4tm1Lwe/Ddit4tm1Lwe
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddit4tm1Lwe mutation (0 available); any Ddit4 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell morphology ( J:99368 )
• following energy stress (induced by treatment with 2-deoxyglucose) mutant MEFs display a less pronounced decrease in cell size compared to wild-type cells; however under normal conditions no differences in cell size or proliferation are seen
• following ATP depletion mutant MEFs are resistant to dephosphorylation of RPS6K and EIF4EBP1




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory