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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sin3atm1.1Rdp
targeted mutation 1.1, Ronald DePinho
MGI:3583656
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sin3atm1.1Rdp/Sin3atm1.1Rdp involves: 129 MGI:3617474
cx2
 		Sin3atm1.1Rdp/Sin3a+
Trp53tm1Tyj/Trp53tm1Tyj 		involves: 129S2/SvPas * C57BL/6 * FVB MGI:3698865


Genotype
MGI:3617474
hm1
Allelic
Composition		 Sin3atm1.1Rdp/Sin3atm1.1Rdp
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sin3atm1.1Rdp mutation (0 available); any Sin3a mutation (62 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3698865
cx2
Allelic
Composition		 Sin3atm1.1Rdp/Sin3a+
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sin3atm1.1Rdp mutation (0 available); any Sin3a mutation (62 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:117829 )
N
• mice show identical tumor incidence, tumor multiplicity, and tumor spectrum to mice with a Sin3a-sufficient, Trp53-null background




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory