Phenotypes associated with this allele

• Allele Symbol: Psen1^tm1Tak
• Allele Name: targeted mutation 1, Junji Takeda
• Allele ID: MGI:3583662
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Psen1^tm1Tak/Psen1^tm1Tak	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3589555
ht2	Psen1^tm1Tak/Psen1^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5795582

Genotype
MGI:3589555

hm1

• Allelic Composition: Psen1^tm1Tak/Psen1^tm1Tak
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal spatial learning ( J:99353 )

• during place learning in a Morris water maze homozygotes have increased quadrant entries and escape latencies compared to wild-type mice; however motor coordination and swimming ability are not impaired and performance in the probe trial is normal

increased startle reflex ( J:99353 )

• homozygotes are more likely than wild-type mice to display whole-body startle following an auditory stimulus

increased grip strength ( J:99353 )

• homozygotes display a tighter grip response on a horizontal grid

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:99353

Genotype
MGI:5795582

ht2

• Allelic Composition: Psen1^tm1Tak/Psen1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

nervous system

abnormal brain morphology ( J:108326 )

• mice show increased levels of amyloid beta(1-42) peptide, however amyloid beta fails to deposit in the brains

neurofibrillary tangles ( J:108326 )

• some hippocampal neurons exhibit Congo red birefringence and Thioflavin T reactivity, indicating neurofibrillary tangles

tau protein deposits ( J:108326 )

• mice exhibit formation of tau inclusions starting at 7 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease 3		DOID:0110042	OMIM:607822	J:108326