Phenotypes associated with this allele

• Allele Symbol: Ms4a2^tm1Chr
• Allele Name: targeted mutation 1, Chisei Ra
• Allele ID: MGI:3583705
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ms4a2^tm1Chr/Ms4a2^tm1Chr	involves: 129S1/Sv * 129X1/SvJ	MGI:3584138

Genotype
MGI:3584138

hm1

• Allelic Composition: Ms4a2^tm1Chr/Ms4a2^tm1Chr
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal mast cell physiology ( J:53106 )

• in vitro IgE dependent degranulation is absent in both bone marrow mast cells and connective tissue-type mast cells

• in vitro adhesion to fibronectin and Ca²⁺ flux are increased when bone marrow mast cells are saturated with 2.4G2 and triggered with a second antibody

• in vitro degranulation of connective tissue-type mast cells is decreased when saturated with 2.4G2 and triggered with a second antibody

decreased susceptibility to type I hypersensitivity reaction ( J:53106 )

• passive cutaneous anaphylaxis (PCA) induced by heat-aggregated IgG is reduced and IgE dependent PCA is absent

hematopoietic system

abnormal mast cell physiology ( J:53106 )

• in vitro IgE dependent degranulation is absent in both bone marrow mast cells and connective tissue-type mast cells

• in vitro adhesion to fibronectin and Ca²⁺ flux are increased when bone marrow mast cells are saturated with 2.4G2 and triggered with a second antibody

• in vitro degranulation of connective tissue-type mast cells is decreased when saturated with 2.4G2 and triggered with a second antibody