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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gsdmetm1Ant
targeted mutation 1, University of Antwerp
MGI:3583715
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gsdmetm1Ant/Gsdmetm1Ant B6.129P2-Gsdmetm1Ant MGI:3584149
hm2
 		Gsdmetm1Ant/Gsdmetm1Ant CBACa.129P2-Gsdmetm1Ant MGI:3584150
cx3
 		Gsdmetm1Ant/Gsdmetm1Ant
Pjvktm1Ugds/Pjvktm1Ugds 		involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6 * CBA/Ca MGI:3654322


Genotype
MGI:3584149
hm1
Allelic
Composition		 Gsdmetm1Ant/Gsdmetm1Ant
Genetic
Background		 B6.129P2-Gsdmetm1Ant
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gsdmetm1Ant mutation (0 available); any Gsdme mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:99624 )
N
• hearing, the structure of the inner and middle ear, and the number of cochlear ganglion cells are not significantly different from wild-type mice
increased cochlear outer hair cell number ( J:99624 )
• extra outer hair cells are seen in the fourth row of outer hair cells in the apical turn and cultured explants of the organ of Corti have extra hair cells in the middle portion of the cochlea

nervous system
increased cochlear outer hair cell number ( J:99624 )
• extra outer hair cells are seen in the fourth row of outer hair cells in the apical turn and cultured explants of the organ of Corti have extra hair cells in the middle portion of the cochlea




Genotype
MGI:3584150
hm2
Allelic
Composition		 Gsdmetm1Ant/Gsdmetm1Ant
Genetic
Background		 CBACa.129P2-Gsdmetm1Ant
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gsdmetm1Ant mutation (0 available); any Gsdme mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:99624 )
N
• hearing, the structure of the inner and middle ear, and the number of cochlear ganglion cells is not significantly different from wild-type mice
decreased cochlear outer hair cell number ( J:99624 )
• fewer outer hair cells are seen in the fourth row of outer hair cells in the apical turn however no difference in hair cell numbers is seen in cultured explants of the organ of Corti

nervous system
decreased cochlear outer hair cell number ( J:99624 )
• fewer outer hair cells are seen in the fourth row of outer hair cells in the apical turn however no difference in hair cell numbers is seen in cultured explants of the organ of Corti




Genotype
MGI:3654322
cx3
Allelic
Composition		 Gsdmetm1Ant/Gsdmetm1Ant
Pjvktm1Ugds/Pjvktm1Ugds
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gsdmetm1Ant mutation (0 available); any Gsdme mutation (42 available)
Pjvktm1Ugds mutation (0 available); any Pjvk mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
increased or absent threshold for auditory brainstem response ( J:111260 )
• hearing loss is identical to Dfnb59 homozygous mice that are wild-type for Dfna5h, indicating that Dfna5h mutation does not modify the phenotype for Dfnb59 mutations




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory