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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zfpm1tm4Sho
targeted mutation 4, Stuart Orkin
MGI:3583784
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Zfpm1tm4Sho/Zfpm1tm4Sho
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: 129S6/SvEvTac * C57BL/6 * CBA MGI:3586444
cn2
 		Zfpm1tm4Sho/Zfpm1tm4Sho
Tg(Gata1-Zfpm1)1Sho/0
Tg(Tek-cre)1Ywa/0 		involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL MGI:3586390


Genotype
MGI:3586444
cn1
Allelic
Composition		 Zfpm1tm4Sho/Zfpm1tm4Sho
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Zfpm1tm4Sho mutation (0 available); any Zfpm1 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:99745 )
N
• viable and do not display double outlet right ventricle or other cardiac defects at E14.5




Genotype
MGI:3586390
cn2
Allelic
Composition		 Zfpm1tm4Sho/Zfpm1tm4Sho
Tg(Gata1-Zfpm1)1Sho/0
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Gata1-Zfpm1)1Sho mutation (0 available)
Tg(Tek-cre)1Ywa mutation (6 available)
Zfpm1tm4Sho mutation (0 available); any Zfpm1 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
thin myocardium ( J:99745 )
• variably thinner than wild type but not as thin as that seen in the Zfpm1 knockout embryos
double outlet right ventricle ( J:99745 )
• observe a small degree of conal rotation, resulting in a slightly more rostral origin of the aorta from the right ventricle compared with that of the pulmonary artery
common atrioventricular valve ( J:99745 )
• have a single common atrioventricular valve

muscle
thin myocardium ( J:99745 )
• variably thinner than wild type but not as thin as that seen in the Zfpm1 knockout embryos




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory