Phenotypes associated with this allele

• Allele Symbol: Zfpm1^tm4Sho
• Allele Name: targeted mutation 4, Stuart Orkin
• Allele ID: MGI:3583784
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Zfpm1^tm4Sho/Zfpm1^tm4Sho H2az2^Tg(Wnt1-cre)11Rth/H2az2^+	involves: 129S6/SvEvTac * C57BL/6 * CBA	MGI:3586444
cn2	Zfpm1^tm4Sho/Zfpm1^tm4Sho Tg(Gata1-Zfpm1)1Sho/0 Tg(Tek-cre)1Ywa/0	involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL	MGI:3586390

Genotype
MGI:3586444

cn1

• Allelic Composition: Zfpm1^tm4Sho/Zfpm1^tm4Sho; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:99745 )

N • viable and do not display double outlet right ventricle or other cardiac defects at E14.5

Genotype
MGI:3586390

cn2

• Allelic Composition: Zfpm1^tm4Sho/Zfpm1^tm4Sho; Tg(Gata1-Zfpm1)1Sho/0; Tg(Tek-cre)1Ywa/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

cardiovascular system

thin myocardium ( J:99745 )

• variably thinner than wild type but not as thin as that seen in the Zfpm1 knockout embryos

double outlet right ventricle ( J:99745 )

• observe a small degree of conal rotation, resulting in a slightly more rostral origin of the aorta from the right ventricle compared with that of the pulmonary artery

common atrioventricular valve ( J:99745 )

• have a single common atrioventricular valve

atrial septal defect ( J:99745 )

atrioventricular septal defect ( J:99745 )

ventricular septal defect ( J:99745 )

muscle

thin myocardium ( J:99745 )

• variably thinner than wild type but not as thin as that seen in the Zfpm1 knockout embryos