immune system
• homozygous macrophages do not show an obvious increase in Ca2+ concentration after chemokine stimulation unlike wild-type macrophages
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• inflammation in response to subcutaneous carrageenan stimulation is reduced and only 20% of the cells in the infiltrate are macrophages compared to 70% in wild-type mice
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• inflammation in response to subcutaneous carrageenan stimulation is reduced with only 2.8 x 106 cells per injected area compared to 4.8 x 106 cells per injected area in wild-type mice
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cellular
• inflammation in response to subcutaneous carrageenan stimulation is reduced and only 20% of the cells in the infiltrate are macrophages compared to 70% in wild-type mice
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hematopoietic system
• homozygous macrophages do not show an obvious increase in Ca2+ concentration after chemokine stimulation unlike wild-type macrophages
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• inflammation in response to subcutaneous carrageenan stimulation is reduced and only 20% of the cells in the infiltrate are macrophages compared to 70% in wild-type mice
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