Phenotypes associated with this allele

• Allele Symbol: Cldn19^tm1Sts
• Allele Name: targeted mutation 1, Shoichiro Tsukita
• Allele ID: MGI:3583804
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cldn19^tm1Sts/Cldn19^tm1Sts	involves: 129S4/SvJae * C57BL/6	MGI:3583999

Genotype
MGI:3583999

hm1

• Allelic Composition: Cldn19^tm1Sts/Cldn19^tm1Sts
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Absence of tight junctions in peripheral myelinated axons of Cldn19^tm1Sts/Cldn19^tm1Sts mice

behavior/neurological

impaired coordination ( J:99659 )

• on beam test, mutant mice slips more than control

• on rotarod test, mutant mice fell from the rod more quickly than control

abnormal gait ( J:99659 )

• mutant mice walk awkwardly on a smooth surface, especially on a smooth rod

nervous system

abnormal Schwann cell morphology ( J:99659 )

• tight junctions are absent from myelinated Schwann cells from their outer/inner mesaxons