All Phenotypes Ptk2<tm1.1Guan> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Myl2^tm1(cre)Krc/Myl2⁺ Ptk2^tm1.1Guan/Ptk2^tm1.1Guan	involves: 129P2/OlaHsd * 129S4/SvJae	MGI:3689728
cn2	Ptk2^tm1.1Guan/Ptk2^tm1.1Guan Tg(Tek-cre)12Flv/0	involves: 129P2/OlaHsd * C3H * C57BL/6	MGI:4820573
cn3	Ptk2^tm1.1Guan/Ptk2^tm1.2Guan Tg(Tek-cre)12Flv/0	involves: 129P2/OlaHsd * C3H * C57BL/6 * C57BL/6J	MGI:3583921
cn4	Ptk2^tm2.1Guan/Ptk2^tm1.1Guan Tg(Tek-cre)12Flv/0	involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N	MGI:4820572

Allelic Composition	Myl2^tm1(cre)Krc/Myl2⁺ Ptk2^tm1.1Guan/Ptk2^tm1.1Guan
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myl2^tm1(cre)Krc mutation (2 available); any Myl2 mutation (22 available)
Ptk2^tm1.1Guan mutation (1 available); any Ptk2 mutation (91 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal myocardium layer morphology ( J:105371 )

abnormal myocardial fiber morphology ( J:105371 )

• cardiomyocytes of older mutants (9 months of age) exhibit increased length but not width

disorganized myocardium ( J:105371 )

• myocardium of older mutants (9 months of age) shows disorganized myofibrils with increased nonmyofibrillar space filled with swelled mitochondria

cardiac hypertrophy ( J:105371 )

• develop eccentric cardiac hypertrophy (normal left ventricle wall thickness and increased left chamber dimension) upon stimulation with angiotensin II or pressure overload by transverse aortic constriction, exhibiting an increase in heart/body weight ratios and elevated markers of cardiac hypertrophy

dilated heart left ventricle ( J:105371 )

• older mutants develop spontaneous cardiac chamber dilation

cardiac interstitial fibrosis ( J:105371 )

• develop multifocal interstitial fibrosis upon stimulation with angiotensin II

muscle

abnormal myocardium layer morphology ( J:105371 )

abnormal myocardial fiber morphology ( J:105371 )

• cardiomyocytes of older mutants (9 months of age) exhibit increased length but not width

disorganized myocardium ( J:105371 )

• myocardium of older mutants (9 months of age) shows disorganized myofibrils with increased nonmyofibrillar space filled with swelled mitochondria

growth/size/body

cardiac hypertrophy ( J:105371 )

cellular

cardiac interstitial fibrosis ( J:105371 )

• develop multifocal interstitial fibrosis upon stimulation with angiotensin II

Allelic Composition	Ptk2^tm1.1Guan/Ptk2^tm1.1Guan Tg(Tek-cre)12Flv/0
Genetic Background	involves: 129P2/OlaHsd * C3H * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptk2^tm1.1Guan mutation (1 available); any Ptk2 mutation (91 available)
Tg(Tek-cre)12Flv mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:162690 )

• fewer mutant embryos than Mendelian ratio at E13.5

• no live mutant embryos at E14.5

cellular

increased apoptosis ( J:162690 )

• increased apoptosis in the liver, brain, placenta and skin at E13.5

• presence of apoptotic endothelial cells (ECs) in the blood vessel of the brain and skin

• increased apoptosis after recombinant adenoviruses encoding Cre (Ad-Cre) infection of the ECs in vitro

growth/size/body

decreased embryo size ( J:162690 )

• at E14.5 and E15.5

embryo

abnormal placenta vasculature ( J:162690 )

• lack of vessels containing nucleated red blood cells in placenta at E13.5

abnormal vitelline vasculature morphology ( J:162690 )

• reduced vascular network in mutant yolk sac at E13.5

decreased embryo size ( J:162690 )

• at E14.5 and E15.5

thin placenta labyrinth ( J:162690 )

• decrease in the thickness of the labyrinth layer of the placenta at E13.5

cardiovascular system

abnormal blood vessel morphology ( J:162690 )

• fewer blood vessels in the brain, spinal cord and skin at E13.5

abnormal placenta vasculature ( J:162690 )

• lack of vessels containing nucleated red blood cells in placenta at E13.5

abnormal vitelline vasculature morphology ( J:162690 )

• reduced vascular network in mutant yolk sac at E13.5

dilated vasculature ( J:162690 )

• dilation of vessels in the brain, spinal cord and skin at E12.5

hemorrhage ( J:162690 )

• perivascular hemorrhages at E13.5

increased vascular permeability ( J:162690 )

• increased permeability after Ad-Cre infection of ECs in vitro

homeostasis/metabolism

edema ( J:162690 )

• at E13.5

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:99637 )

• mutant embryos are progressively lost starting at E13.5 with only 3% of pups at birth having the conditional null genotype

cardiovascular system

abnormal vascular endothelial cell morphology ( J:99637 )

• endothelial cells lining small capillaries have pyknotic and karyorrhetic changes and many are rounded, detached, and sloughing off into the lumen

• apoptotic and necrotic endothelial cells are seen

abnormal capillary morphology ( J:99637 )

• many capillaries with abnormal endothelial cells are collapsed

abnormal placenta vasculature ( J:99637 )

• arterial canals and canal branches lack fetal red blood cells and some of the vessels appear collapsed; however the heart appears normal

abnormal vascular branching morphogenesis ( J:99637 )

• at E13.5, the vascular network in the head is reduced and no clear outlines of viscera or axial skeleton with PECAM-1 staining

abnormal vitelline vasculature morphology ( J:99637 )

• fewer branched vessels and a marked decrease in sprouting angiogenesis are seen in the yolk sac

hemorrhage ( J:99637 )

• at E13.5, multifocal, scattered, and variably sized hemorrhages are seen and at E14.5 these are large and superficial

• at E13.5, the thickened dermis also has numerous perivascular hemorrhages

embryo

abnormal placenta vasculature ( J:99637 )

• arterial canals and canal branches lack fetal red blood cells and some of the vessels appear collapsed; however the heart appears normal

abnormal vitelline vasculature morphology ( J:99637 )

• fewer branched vessels and a marked decrease in sprouting angiogenesis are seen in the yolk sac

embryonic growth retardation ( J:99637 )

• seen in about 5% of embryos at E10.5

decreased embryo size ( J:99637 )

abnormal amnion morphology ( J:99637 )

• thickening of the amnion as a result of edema

• prominent amniotic blood vessels are not seen

thin placenta labyrinth ( J:99637 )

• the thickness of the placental labyrinth is reduced

homeostasis/metabolism

edema ( J:99637 )

• present in the membranes of the amnion at E13.5 and superficially at E14.5

growth/size/body

embryonic growth retardation ( J:99637 )

• seen in about 5% of embryos at E10.5

decreased embryo size ( J:99637 )

integument

thick dermal layer ( J:99637 )

• at E13.5, thickening and expansion of the dermis with loosely arranged mesenchymal cells mixed with acellular pale esosinophilic material

Allelic Composition	Ptk2^tm2.1Guan/Ptk2^tm1.1Guan Tg(Tek-cre)12Flv/0
Genetic Background	involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptk2^tm1.1Guan mutation (1 available); any Ptk2 mutation (91 available)
Ptk2^tm2.1Guan mutation (1 available); any Ptk2 mutation (91 available)
Tg(Tek-cre)12Flv mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:162690 )

• fewer mutant embryos are recovered than Mendelian ratios starting at embryonic day (E)14.5; none are alive at birth

• no perivascular hemorrhages, normal vessels containing nucleated red blood cells, normal vascularization in placenta at E13.5

cardiovascular system

abnormal blood vessel morphology ( J:162690 )

• decreased number of vessels in the brain, spinal cord and skin at E13.5

dilated vasculature ( J:162690 )

• dilated vessels in the brain, spinal cord and skin at E12.5

increased vascular permeability ( J:162690 )

• increased permeability after recombinant adenoviruses encoding Cre infection of endothelial cells in vitro

cellular

increased apoptosis ( J:162690 )

• a slight increase in apoptosis in the liver at E13.5

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