Phenotypes associated with this allele

• Allele Symbol: Tph1^tm1Mlt
• Allele Name: targeted mutation 1, Jacques Mallet
• Allele ID: MGI:3583821
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tph1^tm1Mlt/Tph1^tm1Mlt	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)	MGI:3584535

Genotype
MGI:3584535

hm1

• Allelic Composition: Tph1^tm1Mlt/Tph1^tm1Mlt
• Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

enlarged heart ( J:99733 )

• in some homozygotes heart size is increased by an average of about 26%

decreased cardiac output ( J:99733 )

decreased cardiac stroke volume ( J:99733 )

• mean stroke volume is decreased

decreased cardiac muscle contractility ( J:99733 )

• pressure-volume loops indicate subnormal contractility in some cases and in other cases severe heart failure

abnormal heart left ventricle pressure ( J:99733 )

• left ventricular systolic blood pressure shows greater variability in homozygotes

increased heart rate ( J:99733 )

• homozygous heart rates ranged from 270 -430 bpm compared to 226 - 294 bpm in wild-type mice

behavior/neurological

fatigue ( J:99733 )

respiratory system

respiratory distress ( J:99733 )

• breathing difficulties

muscle

decreased cardiac muscle contractility ( J:99733 )

• pressure-volume loops indicate subnormal contractility in some cases and in other cases severe heart failure

homeostasis/metabolism

decreased serotonin level ( J:99733 )

• serotonin levels are slightly reduced in the brainstem, severely reduced in the gut, blood, heart, lung, and kidney, and barely detectable in the pineal gland

integument

pallor ( J:99733 )

• progressive pallor

growth/size/body

enlarged heart ( J:99733 )

• in some homozygotes heart size is increased by an average of about 26%