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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gna13tm2Cgh
targeted mutation 2, Shaun R Coughlin
MGI:3583876
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gna12tm1Citb/Gna12tm1Citb
Gna13tm2Cgh/Gna13tm2Cgh
Grhl3tm1(cre)Cgh/Grhl3+ 		involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae * C57BL/6 * SJL MGI:4438090
cn2
 		Gna13tm2Cgh/Gna13tm2Cgh
Grhl3tm1(cre)Cgh/Grhl3+ 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL MGI:4431052
cn3
 		Gna13tm1Soff/Gna13tm2Cgh
Tg(Tek-cre)1Ywa/0 		involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * SJL MGI:3590664
cn4
 		Gna12tm1.1Cgh/Gna12tm1.1Cgh
Gna13tm2Cgh/Gna13tm2Cgh
Tg(Mx1-cre)1Cgn/0 		involves: 129S4/SvJae * C57BL/6 * CBA MGI:5140845


Genotype
MGI:4438090
cn1
Allelic
Composition		 Gna12tm1Citb/Gna12tm1Citb
Gna13tm2Cgh/Gna13tm2Cgh
Grhl3tm1(cre)Cgh/Grhl3+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna12tm1Citb mutation (0 available); any Gna12 mutation (21 available)
Gna13tm2Cgh mutation (0 available); any Gna13 mutation (12 available)
Grhl3tm1(cre)Cgh mutation (1 available); any Grhl3 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:157446 )
• mutants die by 10.5 days post coitus (dpc)

embryo
abnormal embryo development ( J:157446 )
• embryos display turning defects and other defects, but the hindbrain neuropore is closed in mutants at 10.5 dpc
abnormal embryo turning ( J:157446 )
• embryos show turning defects




Genotype
MGI:4431052
cn2
Allelic
Composition		 Gna13tm2Cgh/Gna13tm2Cgh
Grhl3tm1(cre)Cgh/Grhl3+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna13tm2Cgh mutation (0 available); any Gna13 mutation (12 available)
Grhl3tm1(cre)Cgh mutation (1 available); any Grhl3 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:157446 )
N
• embryos live through 14.5 days post coitus

nervous system
nervous system phenotype ( J:157446 )
N
• exencephaly is not observed in mutant embryos through E14.5




Genotype
MGI:3590664
cn3
Allelic
Composition		 Gna13tm1Soff/Gna13tm2Cgh
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna13tm1Soff mutation (0 available); any Gna13 mutation (12 available)
Gna13tm2Cgh mutation (0 available); any Gna13 mutation (12 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, incomplete penetrance ( J:99731 )
• at E9.5 36% of mutants are dead and by E11.5 88% are dead

cardiovascular system
abnormal vitelline vasculature morphology ( J:99731 )
• large vessels are missing and unusually large vascular spaces are present; however this phenotype is more obvious in Gna13tm1Soff homozygous mice
enlarged pericardium ( J:99731 )
• pericardial swelling
hemorrhage ( J:99731 )
• variable bleeding into cavities and tissues is seen; however this phenotype is more obvious in Gna13tm1Soff homozygous mice

embryo
abnormal vitelline vasculature morphology ( J:99731 )
• large vessels are missing and unusually large vascular spaces are present; however this phenotype is more obvious in Gna13tm1Soff homozygous mice
excessive folding of visceral yolk sac ( J:99731 )
• the yolk sac is wrinkled

growth/size/body
embryonic growth retardation ( J:99731 )

integument




Genotype
MGI:5140845
cn4
Allelic
Composition		 Gna12tm1.1Cgh/Gna12tm1.1Cgh
Gna13tm2Cgh/Gna13tm2Cgh
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna12tm1.1Cgh mutation (0 available); any Gna12 mutation (21 available)
Gna13tm2Cgh mutation (0 available); any Gna13 mutation (12 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell apoptosis ( J:174313 )
• in pIpC-treated mice
abnormal germinal center B cell morphology ( J:174313 )
• germinal center B cells in pIpC-treated mice exhibit a tendency to segregate from wild-type germinal center B cells
increased germinal center B cell number ( J:174313 )
• in mucosal germinal centers when bone marrow cells are used to reconstitute wild-type mice treated with pIpC

hematopoietic system
decreased B cell apoptosis ( J:174313 )
• in pIpC-treated mice
abnormal germinal center B cell morphology ( J:174313 )
• germinal center B cells in pIpC-treated mice exhibit a tendency to segregate from wild-type germinal center B cells
increased germinal center B cell number ( J:174313 )
• in mucosal germinal centers when bone marrow cells are used to reconstitute wild-type mice treated with pIpC

cellular
decreased B cell apoptosis ( J:174313 )
• in pIpC-treated mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
08/02/2024
MGI 6.24 		The Jackson Laboratory