About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mcm3aptm1Imku
targeted mutation 1, Nobuo Sakaguchi
MGI:3583894
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Mcm3aptm1Imku/Mcm3aptm1Imku
Cd19tm1(cre)Cgn/Cd19+ 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3584126


Genotype
MGI:3584126
cn1
Allelic
Composition		 Mcm3aptm1Imku/Mcm3aptm1Imku
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Mcm3aptm1Imku mutation (0 available); any Mcm3ap mutation (78 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell proliferation ( J:88276 )
• B cell proliferation is slightly impaired in response to CD40/CD50 stimulation but not in response to LPS stimulation
abnormal memory B cell number ( J:88276 )
• decrease in the memory B cell population
decreased germinal center B cell number ( J:88276 )
• decrease in the germinal center B cell population
abnormal spleen germinal center morphology ( J:88276 )
• germinal center formation is delayed in response to T cell dependent antigen stimulation
abnormal germinal center B cell physiology ( J:88276 )
• after antigen stimulation increased apoptosis is seen in germinal center B cells
decreased IgG level ( J:88276 )
• antibody response (IgG1) to NP25-BSA is markedly reduced with the decrease occurring because of a decrease in the germinal center B cell and memory B cell populations

hematopoietic system
decreased B cell proliferation ( J:88276 )
• B cell proliferation is slightly impaired in response to CD40/CD50 stimulation but not in response to LPS stimulation
abnormal memory B cell number ( J:88276 )
• decrease in the memory B cell population
decreased germinal center B cell number ( J:88276 )
• decrease in the germinal center B cell population
abnormal spleen germinal center morphology ( J:88276 )
• germinal center formation is delayed in response to T cell dependent antigen stimulation
abnormal germinal center B cell physiology ( J:88276 )
• after antigen stimulation increased apoptosis is seen in germinal center B cells
decreased IgG level ( J:88276 )
• antibody response (IgG1) to NP25-BSA is markedly reduced with the decrease occurring because of a decrease in the germinal center B cell and memory B cell populations

cellular
decreased B cell proliferation ( J:88276 )
• B cell proliferation is slightly impaired in response to CD40/CD50 stimulation but not in response to LPS stimulation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory