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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ipmktm1Yrk
targeted mutation 1, John D York
MGI:3583918
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ipmktm1Yrk/Ipmktm1Yrk involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:3584532


Genotype
MGI:3584532
hm1
Allelic
Composition
Ipmktm1Yrk/Ipmktm1Yrk
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ipmktm1Yrk mutation (1 available); any Ipmk mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Morphological analysis of Ipmktm1Yrk/Ipmktm1Yrk embryos

mortality/aging
• homozygous embryos die between E10.5 and E12.5

embryo
• at E9.5 homozygous embryos are not turned
• at E8.5 embryos appear developmentally delayed
• at E8.5 homozygous embryos are smaller and shorter along the anterior to posterior axis
• at E9.5 homozygous embryos are about 20% smaller than their littermates
• at E9.5 the anterior neural tube is open
• at E9.5 the neural tube is kinked and folded
• at E8.5 and E9.5, the allantois is not fused to the chorion

nervous system
• at E9.5 the anterior neural tube is open
• at E9.5 the neural tube is kinked and folded
• at E8.5 massive accumulation and folding of the neurectoderm is seen in the mid-hind region

growth/size/body
• at E8.5 embryos appear developmentally delayed
• at E8.5 homozygous embryos are smaller and shorter along the anterior to posterior axis
• at E9.5 homozygous embryos are about 20% smaller than their littermates





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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory