About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ipmktm1Yrk
targeted mutation 1, John D York
MGI:3583918
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ipmktm1Yrk/Ipmktm1Yrk involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:3584532


Genotype
MGI:3584532
hm1
Allelic
Composition
Ipmktm1Yrk/Ipmktm1Yrk
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ipmktm1Yrk mutation (1 available); any Ipmk mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Morphological analysis of Ipmktm1Yrk/Ipmktm1Yrk embryos

mortality/aging
• homozygous embryos die between E10.5 and E12.5

embryo
• at E9.5 homozygous embryos are not turned
• at E8.5 embryos appear developmentally delayed
• at E8.5 homozygous embryos are smaller and shorter along the anterior to posterior axis
• at E9.5 homozygous embryos are about 20% smaller than their littermates
• at E9.5 the anterior neural tube is open
• at E9.5 the neural tube is kinked and folded
• at E8.5 and E9.5, the allantois is not fused to the chorion

nervous system
• at E9.5 the anterior neural tube is open
• at E9.5 the neural tube is kinked and folded
• at E8.5 massive accumulation and folding of the neurectoderm is seen in the mid-hind region

growth/size/body
• at E8.5 embryos appear developmentally delayed
• at E8.5 homozygous embryos are smaller and shorter along the anterior to posterior axis
• at E9.5 homozygous embryos are about 20% smaller than their littermates





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/22/2024
MGI 6.24
The Jackson Laboratory