mortality/aging
• homozygous embryos die between E10.5 and E12.5
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embryo
• at E9.5 homozygous embryos are not turned
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• at E8.5 embryos appear developmentally delayed
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• at E8.5 homozygous embryos are smaller and shorter along the anterior to posterior axis
• at E9.5 homozygous embryos are about 20% smaller than their littermates
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• at E9.5 the anterior neural tube is open
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• at E9.5 the neural tube is kinked and folded
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• at E8.5 and E9.5, the allantois is not fused to the chorion
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nervous system
• at E9.5 the anterior neural tube is open
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• at E9.5 the neural tube is kinked and folded
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• at E8.5 massive accumulation and folding of the neurectoderm is seen in the mid-hind region
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growth/size/body
• at E8.5 embryos appear developmentally delayed
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• at E8.5 homozygous embryos are smaller and shorter along the anterior to posterior axis
• at E9.5 homozygous embryos are about 20% smaller than their littermates
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