Phenotypes associated with this allele

• Allele Symbol: Myc^tm1Lbox
• Allele Name: targeted mutation 1, Linda M Boxer
• Allele ID: MGI:3583919
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myc^tm1Lbox/Myc^tm1Lbox	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:3603014
ht2	Myc^tm1Lbox/Myc^+	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:3603015

Genotype
MGI:3603014

hm1

• Allelic Composition: Myc^tm1Lbox/Myc^tm1Lbox
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Histopathological analysis of lymphomas in Myc^tm1Lbox/Myc^tm1Lbox and Myc^tm1Lbox/Myc⁺ mice

mortality/aging

premature death ( J:97900 )

• mean age of death is about 314 days

immune system

increased B cell apoptosis ( J:97900 )

• increased apoptosis of B cells from young homozygotes is seen in culture without activating stimuli; however, B cells from lymphomas remain viable in culture for longer periods of time compared to wild-type cells

increased B cell proliferation ( J:97900 )

• antigen-stimulated B cell proliferation is increased about 2-fold compared to wild-type mice and the number of B cells in S and G₂/M phase is increased to 47% compared to 24% of wild-type B cells

enlarged spleen ( J:97900 )

• around 10 months of age, a profound enlargement of the spleen is seen

increased spleen weight ( J:97900 )

• around 10 months of age, a 5-12 fold increase in spleen weight is seen

increased B cell number ( J:97900 )

• in young (6 weeks-3months) mutants, the percentage of B cells in the spleen is increased with a 7-10 fold increase in the B220+IgM+IgD^low cell population and a slight increase in the B220+IgM+ cell population is seen in the bone marrow

decreased T cell number ( J:97900 )

• in young (6 weeks-3months) mutants, the percentage of T cells in the spleen is decreased; however T cell development in the thymus is normal and the ratio of CD4 and CD8 cells is similar to wild-type

enlarged lymph nodes ( J:97900 )

• around 10 months of age profound enlargement of the lymph nodes is seen

neoplasm

increased B cell derived lymphoma incidence ( J:97900 )

• B cell derived lymphomas with diffuse infiltration in the spleen and lymph nodes, varying degrees of infiltration into the lung, kidney, and intestine, and a 'starry sky' appearance characteristic of Burkitt's lymphoma are seen

hematopoietic system

increased B cell apoptosis ( J:97900 )

• increased apoptosis of B cells from young homozygotes is seen in culture without activating stimuli; however, B cells from lymphomas remain viable in culture for longer periods of time compared to wild-type cells

increased B cell proliferation ( J:97900 )

• antigen-stimulated B cell proliferation is increased about 2-fold compared to wild-type mice and the number of B cells in S and G₂/M phase is increased to 47% compared to 24% of wild-type B cells

enlarged spleen ( J:97900 )

• around 10 months of age, a profound enlargement of the spleen is seen

increased spleen weight ( J:97900 )

• around 10 months of age, a 5-12 fold increase in spleen weight is seen

increased B cell number ( J:97900 )

• in young (6 weeks-3months) mutants, the percentage of B cells in the spleen is increased with a 7-10 fold increase in the B220+IgM+IgD^low cell population and a slight increase in the B220+IgM+ cell population is seen in the bone marrow

decreased T cell number ( J:97900 )

• in young (6 weeks-3months) mutants, the percentage of T cells in the spleen is decreased; however T cell development in the thymus is normal and the ratio of CD4 and CD8 cells is similar to wild-type

cellular

increased B cell apoptosis ( J:97900 )

• increased apoptosis of B cells from young homozygotes is seen in culture without activating stimuli; however, B cells from lymphomas remain viable in culture for longer periods of time compared to wild-type cells

increased B cell proliferation ( J:97900 )

• antigen-stimulated B cell proliferation is increased about 2-fold compared to wild-type mice and the number of B cells in S and G₂/M phase is increased to 47% compared to 24% of wild-type B cells

growth/size/body

enlarged spleen ( J:97900 )

• around 10 months of age, a profound enlargement of the spleen is seen

increased spleen weight ( J:97900 )

• around 10 months of age, a 5-12 fold increase in spleen weight is seen

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Burkitt lymphoma		DOID:8584	OMIM:113970	J:97900

Genotype
MGI:3603015

ht2

• Allelic Composition: Myc^tm1Lbox/Myc⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Histopathological analysis of lymphomas in Myc^tm1Lbox/Myc^tm1Lbox and Myc^tm1Lbox/Myc⁺ mice

mortality/aging

premature death ( J:97900 )

• mean age of death is about 379 days

immune system

enlarged spleen ( J:97900 )

• around 12 months of age profound enlargement of the spleen is seen

increased spleen weight ( J:97900 )

• around 12 months of age, a 5-12 fold increase in spleen weight seen

increased B cell number ( J:97900 )

• in young (6 weeks-3months) mutants, the percentage of B cells in the spleen is increased with a significant increase in the B220+IgM+IgD^low cell population and a slight increase in the B220+IgM+ cell population is seen in the bone marrow

enlarged lymph nodes ( J:97900 )

• around 12 months of age profound enlargement of the lymph nodes is seen

neoplasm

increased B cell derived lymphoma incidence ( J:97900 )

• B cell derived lymphomas with diffuse infiltration in the spleen and lymph nodes, varying degrees of infiltration into the lung, kidney, and intestine, and a 'starry sky' appearance characteristic of Burkitt's lymphoma are seen

hematopoietic system

enlarged spleen ( J:97900 )

• around 12 months of age profound enlargement of the spleen is seen

increased spleen weight ( J:97900 )

• around 12 months of age, a 5-12 fold increase in spleen weight seen

increased B cell number ( J:97900 )

• in young (6 weeks-3months) mutants, the percentage of B cells in the spleen is increased with a significant increase in the B220+IgM+IgD^low cell population and a slight increase in the B220+IgM+ cell population is seen in the bone marrow

growth/size/body

enlarged spleen ( J:97900 )

• around 12 months of age profound enlargement of the spleen is seen

increased spleen weight ( J:97900 )

• around 12 months of age, a 5-12 fold increase in spleen weight seen

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Burkitt lymphoma		DOID:8584	OMIM:113970	J:97900