Phenotypes associated with this allele

• Allele Symbol: Cspg5^tm1Fgr
• Allele Name: targeted mutation 1, Fritz G Rathjen
• Allele ID: MGI:3583953
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cspg5^tm1Fgr/Cspg5^tm1Fgr	B6.129P2-Cspg5^tm1Fgr	MGI:3584140

Genotype
MGI:3584140

hm1

• Allelic Composition: Cspg5^tm1Fgr/Cspg5^tm1Fgr
• Genetic Background: B6.129P2-Cspg5^tm1Fgr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal CNS synaptic transmission ( J:99761 )

• the release probability calculated for inhibitory synapses is decreased although the estimated readily releasable vesicle pool is not decreased and the morphology of the presynapses appears normal

decreased excitatory postsynaptic current frequency ( J:99761 )

• at 1 - 3 days of age, but not at 20 - 22 days of age, the frequency of spontaneous EPSCs is significantly decreased

abnormal inhibitory postsynaptic currents ( J:99761 )

• at 1 - 3 days of age, but not at 20 - 22 days of age, the frequency of spontaneous IPSCs is significantly decreased; however no differences in action potential generation or repetitive spike generation in response to depolarizing currents are detected and synapse structure appears normal

• at 1 - 3 days of age, but not at 20 - 22 days of age, the amplitude of evoked ISPCs is decreased

reduced long-term depression ( J:99761 )

• at 1 - 3 days of age, but not at 20 - 22 days of age, inhibitory synapses show less depression in the course of prolonged high-frequency activation

enhanced paired-pulse facilitation ( J:99761 )

• at 1 - 3 days of age, but not at 20 - 22 days of age, using either 20 ms or 100 ms interval the paired pulse ratio is increased in homozygotes

behavior/neurological

abnormal maternal nurturing ( J:99761 )

♀ • females do not care for their litters as well as wild-type mice