Analysis Tools
limbs/digits/tail
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• short and deformed hindlimbs
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short tibia
(
J:77639
)
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• shorter and thicker
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short limbs
(
J:77639
)
short tail
(
J:77639
)
skeleton
short tibia
(
J:77639
)
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• shorter and thicker
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• metaphysis is widened in the hindlimbs
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• ossification centers of vertebrae are reduced in size
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• chondrocyte hypertrophy and subsequent blood vessel invasion begins at the periphery of the diaphysis and not in the center of the tibia
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• at birth, show reduced or absent mineralization of many elements that develop by endochondral bone formation such as the supraoccipital bone, sternum, ischium and pubic bone and have severe mineralization defects of the radius and metatarsal bones
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• more pronounced than in Tg(Col2a1-PTHR1*H223R))AHju
• tibiae of newborns consist mainly of proliferative and hypertrophic chondrocytes
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