About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rag1tm1(cre)Thr
targeted mutation 1, Terence H Rabbitts
MGI:3584018
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rag1tm1(cre)Thr/Rag1tm1(cre)Thr Not Specified MGI:3584437
cn2
 		Lmo2tm3Thr/Lmo2tm4Thr
Rag1tm1(cre)Thr/Rag1+ 		involves: 129S/SvEv MGI:3584438
cn3
 		Ewsr1tm1(ERG)Thr/Ewsr1+
Rag1tm1(cre)Thr/Rag1+ 		involves: 129S/SvEv MGI:3603039
cn4
 		Rag1tm1(cre)Thr/?
Shcbp1tm1c(EUCOMM)Wtsi/Shcbp1tm1c(EUCOMM)Wtsi 		involves: C57BL/6N MGI:5582922


Genotype
MGI:3584437
hm1
Allelic
Composition		 Rag1tm1(cre)Thr/Rag1tm1(cre)Thr
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1(cre)Thr mutation (0 available); any Rag1 mutation (121 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal lymphopoiesis ( J:86869 )
• fail to develop lymphocytes
absent lymphocyte ( J:86869 )
• fail to develop lymphocytes

immune system
abnormal lymphopoiesis ( J:86869 )
• fail to develop lymphocytes
absent lymphocyte ( J:86869 )
• fail to develop lymphocytes




Genotype
MGI:3584438
cn2
Allelic
Composition		 Lmo2tm3Thr/Lmo2tm4Thr
Rag1tm1(cre)Thr/Rag1+
Genetic
Background		 involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmo2tm3Thr mutation (0 available); any Lmo2 mutation (31 available)
Lmo2tm4Thr mutation (0 available); any Lmo2 mutation (31 available)
Rag1tm1(cre)Thr mutation (0 available); any Rag1 mutation (121 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:86869 )
N
• mutant mice are viable and exhibit no hematopoietic defects, with normal bone marrow, spleen and thymus cell counts

immune system
immune system phenotype ( J:86869 )
N
• normal T and B lymphoid development




Genotype
MGI:3603039
cn3
Allelic
Composition		 Ewsr1tm1(ERG)Thr/Ewsr1+
Rag1tm1(cre)Thr/Rag1+
Genetic
Background		 involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ewsr1tm1(ERG)Thr mutation (0 available); any Ewsr1 mutation (92 available)
Rag1tm1(cre)Thr mutation (0 available); any Rag1 mutation (121 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased T cell derived lymphoma incidence ( J:98679 )
• associated with leukemia
increased leukemia incidence ( J:98679 )
• mutant mice develop leukemia involving T cells with infiltrating lymphoblasts in the bone marrow, liver, and kidney

immune system
increased lymphocyte cell number ( J:98679 )
• associated with leukemia

hematopoietic system
increased lymphocyte cell number ( J:98679 )
• associated with leukemia

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:98679 )
• associated with leukemia




Genotype
MGI:5582922
cn4
Allelic
Composition		 Rag1tm1(cre)Thr/?
Shcbp1tm1c(EUCOMM)Wtsi/Shcbp1tm1c(EUCOMM)Wtsi
Genetic
Background		 involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1(cre)Thr mutation (0 available); any Rag1 mutation (121 available)
Shcbp1tm1c(EUCOMM)Wtsi mutation (1 available); any Shcbp1 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:212898 )
N
• T cell development appears normal in 2 week old mice
• fraction of absolute numbers of CD4+ and CD8+ T cells in spleen and lymph nodes is similar to controls
• numbers and percentages of thymic compartment subsets in 4-6 week old mice are similar to controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory