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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rag1tm1(cre)Thr
targeted mutation 1, Terence H Rabbitts
MGI:3584018
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rag1tm1(cre)Thr/Rag1tm1(cre)Thr Not Specified MGI:3584437
cn2
 		Lmo2tm3Thr/Lmo2tm4Thr
Rag1tm1(cre)Thr/Rag1+ 		involves: 129S/SvEv MGI:3584438
cn3
 		Ewsr1tm1(ERG)Thr/Ewsr1+
Rag1tm1(cre)Thr/Rag1+ 		involves: 129S/SvEv MGI:3603039
cn4
 		Rag1tm1(cre)Thr/?
Shcbp1tm1c(EUCOMM)Wtsi/Shcbp1tm1c(EUCOMM)Wtsi 		involves: C57BL/6N MGI:5582922


Genotype
MGI:3584437
hm1
Allelic
Composition		 Rag1tm1(cre)Thr/Rag1tm1(cre)Thr
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1(cre)Thr mutation (0 available); any Rag1 mutation (123 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal lymphopoiesis ( J:86869 )
• fail to develop lymphocytes
absent lymphocyte ( J:86869 )
• fail to develop lymphocytes

immune system
abnormal lymphopoiesis ( J:86869 )
• fail to develop lymphocytes
absent lymphocyte ( J:86869 )
• fail to develop lymphocytes




Genotype
MGI:3584438
cn2
Allelic
Composition		 Lmo2tm3Thr/Lmo2tm4Thr
Rag1tm1(cre)Thr/Rag1+
Genetic
Background		 involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmo2tm3Thr mutation (0 available); any Lmo2 mutation (31 available)
Lmo2tm4Thr mutation (0 available); any Lmo2 mutation (31 available)
Rag1tm1(cre)Thr mutation (0 available); any Rag1 mutation (123 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:86869 )
N
• mutant mice are viable and exhibit no hematopoietic defects, with normal bone marrow, spleen and thymus cell counts

immune system
immune system phenotype ( J:86869 )
N
• normal T and B lymphoid development




Genotype
MGI:3603039
cn3
Allelic
Composition		 Ewsr1tm1(ERG)Thr/Ewsr1+
Rag1tm1(cre)Thr/Rag1+
Genetic
Background		 involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ewsr1tm1(ERG)Thr mutation (0 available); any Ewsr1 mutation (93 available)
Rag1tm1(cre)Thr mutation (0 available); any Rag1 mutation (123 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased T cell derived lymphoma incidence ( J:98679 )
• associated with leukemia
increased leukemia incidence ( J:98679 )
• mutant mice develop leukemia involving T cells with infiltrating lymphoblasts in the bone marrow, liver, and kidney

immune system
increased T cell derived lymphoma incidence ( J:98679 )
• associated with leukemia
increased lymphocyte cell number ( J:98679 )
• associated with leukemia

hematopoietic system
increased T cell derived lymphoma incidence ( J:98679 )
• associated with leukemia
increased lymphocyte cell number ( J:98679 )
• associated with leukemia

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:98679 )
• associated with leukemia




Genotype
MGI:5582922
cn4
Allelic
Composition		 Rag1tm1(cre)Thr/?
Shcbp1tm1c(EUCOMM)Wtsi/Shcbp1tm1c(EUCOMM)Wtsi
Genetic
Background		 involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1(cre)Thr mutation (0 available); any Rag1 mutation (123 available)
Shcbp1tm1c(EUCOMM)Wtsi mutation (1 available); any Shcbp1 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:212898 )
N
• T cell development appears normal in 2 week old mice
• fraction of absolute numbers of CD4+ and CD8+ T cells in spleen and lymph nodes is similar to controls
• numbers and percentages of thymic compartment subsets in 4-6 week old mice are similar to controls




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory