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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rrn3tm1.1Igt
targeted mutation 1.1, Ingrid Grummt
MGI:3584035
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rrn3tm1.1Igt/Rrn3tm1.1Igt involves: 129/Sv * C57BL/6 MGI:3716306
cn2
Park7Gt(XE726)Byg/Park7Gt(XE726)Byg
Pink1tm1.1Wrst/Pink1tm1.1Wrst
Rrn3tm1.1Igt/Rrn3tm1.1Igt
Tg(Slc6a3-cre/ERT2)1Span/0
involves: 129 * 129P2/OlaHsd * 129S2/SvPas * C57BL/6J MGI:6113544
cn3
Rrn3tm1.1Igt/Rrn3tm1.1Igt
Tg(Slc6a3-cre/ERT2)1Span/0
involves: 129/Sv * C57BL/6 MGI:6113542
cn4
Rrn3tm1.1Igt/Rrn3tm1.1Igt
Tg(Slc6a3-icre)9190Gsc/0
involves: 129/Sv * C57BL/6 * FVB/N MGI:6113543


Genotype
MGI:3716306
hm1
Allelic
Composition
Rrn3tm1.1Igt/Rrn3tm1.1Igt
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rrn3tm1.1Igt mutation (1 available); any Rrn3 mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
N
• mouse embryonic fibroblast cells are normal




Genotype
MGI:6113544
cn2
Allelic
Composition
Park7Gt(XE726)Byg/Park7Gt(XE726)Byg
Pink1tm1.1Wrst/Pink1tm1.1Wrst
Rrn3tm1.1Igt/Rrn3tm1.1Igt
Tg(Slc6a3-cre/ERT2)1Span/0
Genetic
Background
involves: 129 * 129P2/OlaHsd * 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Park7Gt(XE726)Byg mutation (1 available); any Park7 mutation (54 available)
Pink1tm1.1Wrst mutation (0 available); any Pink1 mutation (42 available)
Rrn3tm1.1Igt mutation (1 available); any Rrn3 mutation (41 available)
Tg(Slc6a3-cre/ERT2)1Span mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• nucleolar integrity is disrupted in dopaminergic neurons of tamoxifen treated mice to a similar level as seen in single conditional Rrn3 mutants
• induction of nucleolar stress is seen in dopaminergic neurons of tamoxifen treated mice to a similar level as seen in single conditional Rrn3 mutants




Genotype
MGI:6113542
cn3
Allelic
Composition
Rrn3tm1.1Igt/Rrn3tm1.1Igt
Tg(Slc6a3-cre/ERT2)1Span/0
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rrn3tm1.1Igt mutation (1 available); any Rrn3 mutation (41 available)
Tg(Slc6a3-cre/ERT2)1Span mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• motor dysfunction in mice injected with tamoxifen at 2 months of age

cellular
• nucleolar integrity is disrupted in dopaminergic neurons of tamoxifen treated mice
• about 40% decrease in COX activity is seen 2 weeks after tamoxifen treatment, indicating mitochondrial damage is an early consequence of nucleolar damage
• induction of nucleolar stress is seen in dopaminergic neurons of tamoxifen treated mice
• dopaminergic neurons of tamoxifen-induced mice are more vulnerable to the oxidative damage induced by MPTP than controls showing an approximate 40% loss of neurons compared to 15% in controls
• dopaminergic neurons show higher levels of oxidative stress markers at 4 weeks after tamoxifen treatment

homeostasis/metabolism
• mice injected with tamoxifen at 2 months of age exhibit a decline in dopamine content in the striatum

nervous system
• mice injected with tamoxifen at 2 months of age show a progressive differential loss of dopaminergic neurons in substantia nigra and ventral tegmental area
• tamoxifen-induced mice treated with pifithrin-alpha, a chemical inhibitor of Trp53 show prevention of dopaminergic neuron loss
• mice injected with tamoxifen at 2 months of age exhibit neurodegeneration of TH+ neurons

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Parkinson's disease DOID:14330 OMIM:PS168600
J:168232 , J:242309




Genotype
MGI:6113543
cn4
Allelic
Composition
Rrn3tm1.1Igt/Rrn3tm1.1Igt
Tg(Slc6a3-icre)9190Gsc/0
Genetic
Background
involves: 129/Sv * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rrn3tm1.1Igt mutation (1 available); any Rrn3 mutation (41 available)
Tg(Slc6a3-icre)9190Gsc mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit abnormal behavior at 4 weeks of age, starting with slowness of movements
• mice show an approximate 55% reduction in motor performance on the accelerating rotarod at 4 weeks of age, reaching a 76% decline at 8 weeks of age
• mice eventually develop twitching similar to Parkinsons disease tremor
• mice exhibit posture disturbances at 4 weeks of age
• mice exhibit abnormal gait at 4 weeks of age

cellular
• nucleolar disruption in dopaminergic neurons is seen at E18.5

growth/size/body
• mice show a progressive reduction in weight gain after P15
• mice with severe phenotype treated with the dopamine precursor L-DOPA survive and grain weight

homeostasis/metabolism
• 95% reduction of dopamine levels at 5 weeks of age

nervous system
• decrease in the number of dopaminergic neurons, with neurons in the substantia nigra more rapidly and severely affected than those in the ventral tegmental area
• TH immunoreactivity in dopaminergic neuron terminals in the striatum is decreased already at P0, before the loss of neurons
• of dopaminergic neurons

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Parkinson's disease DOID:14330 OMIM:PS168600
J:168232





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory