All Phenotypes Rcvrn<tm1Clma> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rcvrn^tm1Clma
targeted mutation 1, C L Makino
MGI:3584102

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rcvrn^tm1Clma/Rcvrn^tm1Clma	involves: 129S/SvEv * 129S1/Sv * C57BL/6	MGI:3584498
hm2	Rcvrn^tm1Clma/Rcvrn^tm1Clma	involves: 129S1/Sv	MGI:3584499
cx3	Guca1a/Guca1b^tm1Jnc/Guca1a/Guca1b^tm1Jnc Rcvrn^tm1Clma/Rcvrn^tm1Clma	involves: 129S1/Sv	MGI:3586546
cx4	Guca1a/Guca1b^tm1Jnc/Guca1a/Guca1b^tm1Jnc Rcvrn^tm1Clma/Rcvrn^tm1Clma	involves: 129S1/Sv	MGI:3586548

Allelic Composition	Rcvrn^tm1Clma/Rcvrn^tm1Clma
Genetic Background	involves: 129S/SvEv * 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rcvrn^tm1Clma mutation (1 available); any Rcvrn mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eye physiology ( J:99760 )

• visual threshold, the light intensity at which the time to find a platform was 50% of that in darkness, is about 4-fold higher than in controls

abnormal eye electrophysiology ( J:99760 )

• shorter integration time of dim flash responses in ganglion cells, rod cells and rod bipolar cells, resulting in a quicker return to baseline

Allelic Composition	Rcvrn^tm1Clma/Rcvrn^tm1Clma
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rcvrn^tm1Clma mutation (1 available); any Rcvrn mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eye electrophysiology ( J:99835 )

• faster flash response recovery in dark-adapted rods

• phosphodiesterase adaptation is absent in rods

• calcium dynamics are accelerated in rods in response to bright, saturating flashes of light

• electroretinograms exhibit two corneal positive b-waves rather than one in response to a single midrange scotopic flash

• sensitivity of rods to steps of lights is decreased

Allelic Composition	Guca1a/Guca1b^tm1Jnc/Guca1a/Guca1b^tm1Jnc Rcvrn^tm1Clma/Rcvrn^tm1Clma
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Guca1a/Guca1b^tm1Jnc mutation (0 available); any Guca1a mutation (12 available)
Rcvrn^tm1Clma mutation (1 available); any Rcvrn mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eye electrophysiology ( J:99835 )

• reduction in the single photon response amplitude and a corresponding increase in the half-saturating flash strength, and shortened time-to-peak and integration time of the dim flash response when compared to homozygous Guca1a/Guca1b^tm1Jnc mutant mice

Allelic Composition	Guca1a/Guca1b^tm1Jnc/Guca1a/Guca1b^tm1Jnc Rcvrn^tm1Clma/Rcvrn^tm1Clma
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Guca1a/Guca1b^tm1Jnc mutation (0 available); any Guca1b mutation (9 available)
Rcvrn^tm1Clma mutation (1 available); any Rcvrn mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eye electrophysiology ( J:99835 )

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