Analysis Tools
mortality/aging
muscle
|
• significant increases in left ventricular wall thickness and mass are seen
|
endocrine/exocrine glands
|
• adrenal ATP levels are decreased by about 87% and the catecholamine/ATP ratio is elevated by about 4.4- to 4.9-fold
|
|
• plasma levels of neuropeptide Y are increased by about 162% and adrenal levels are decreased by about 46%
|
cardiovascular system
|
• significant increases in left ventricular wall thickness and mass are seen
|
hypertension
(
J:99805
)
|
• both systolic and diastolic blood pressure are elevated and the normal daytime decrease in blood pressure does not occur
• treatment with the catecholamine release inhibitory CHGA fragment catestatin significantly reduced blood pressure
|
growth/size/body
|
• significant increases in left ventricular wall thickness and mass are seen
|
|
• growth retardation is seen for the first 4-5 weeks after birth; however homozygotes are the same size as littermates by 7-9 weeks of age
|
homeostasis/metabolism
|
• plasma levels of epinephrine are increased by about 210%
|
|
• plasma levels of norepinephrine are increased by about 214%
|
|
• adrenal levels of epinephrine are decreased by about 39%
|
|
• adrenal levels of norepinephrine are decreased by about 33%
|
|
• adrenal levels of corticosterone are increased by about 406%; however the plasma potassium and renin levels are not increased
|
